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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 3949Generated: October 25, 2026

Lomerizine

KB 2796 · TERRANAS · LOMERIZINE · Flometizine · LOMERIZINE HCL · LOMERIZINE DIHCL · Lomerizine USP/EP/BP · Lomerizine in methanol

https://huagongshe.com/en/chemical/3949

Lomerizine molecular structure

Identifiers & Physical Properties

CAS No.101477-55-8
Molecular formulaC27H30F2N2O3
Average molar mass468.5 g/mol
Monoisotopic mass468.22244926 g/mol
SMILESCOc1ccc(CN2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c(OC)c1OC
InChIKeyJQSAYKKFZOSZGJ-UHFFFAOYSA-N
PubChem CID3949
ChEMBLCHEMBL29188
ChEBICHEBI:94682
EC No.113-385-6
DTXSIDDTXSID6048387

Chemical & Physical Properties

XLogP4.9
Topological polar surface area34.2
Hydrogen bond donors0
Hydrogen bond acceptors7
Rotatable bonds8
Heavy atoms34
Formal charge0
Complexity568
DrugsPharmaceuticals -> Nervous system -> Other nervous system drugsPharmaceuticals -> Listed in ZINC15
Boiling point527.3±45.0 °C(Predicted)
Density1.203±0.06 g/cm3(Predicted)
pKa (acidity coefficient)6.17±0.10(Predicted)
CAS DataBase Reference101477-55-8(CAS DataBase Reference)
FDA UNIIDEE37CY4VO
GHS pictogramGHS07
Signal wordWarning
GHS hazard statementsH302-H315-H319-H335
GHS precautionary statementsP280-P305+P351+P338

Safety & Regulations

GHS classificationWarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Signal wordWarning
GHS pictogramGHS07
GHS hazard statementsH302-H315-H319-H335
GHS precautionary statementsP280-P305+P351+P338

Applications & Uses

Uses

antimigraine, cerebral vasodilator, Ca channel blocker