Basic information
- CAS
49697-38-3- Standard SMILES
CCC(=O)[C@@]1(C)[C@H](C)CC2C3CCC4=CC(=O)C=C[C@]4(C)C3[C@@H](O)C[C@@]21C- InChIKey
QTTRZHGPGKRAFB-PAIWTFDUSA-N- Molecular formula
- C24H34O3
- Average molar mass
- 370.5 g/mol
- Monoisotopic mass
- 370.25079494
Names & identifiers
- Preferred name
- (2R,13R,14S,15S,17S)-17-hydroxy-2,13,14,15-tetramethyl-14-propanoyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
- IUPAC
- (10R,11S,13S,16R,17S)-11-hydroxy-10,13,16,17-tetramethyl-17-propanoyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
- English name
- RIMEXOLONE (100 MG)
- Molecular formula
- C24H34O3
- Molecular weight
- 370.53
Names & synonyms
CHEMBL111461SCHEMBL1651214NS00001936(2R,13R,14S,15S,17S)-17-hydroxy-2,13,14,15-tetramethyl-14-propanoyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-oneRimexoloneVexolRimexelOrg-6216Rimexolone D6Rimexolone D5(11β,16α,17β)-RIMEXOLONE (100 MG)
Show more names
Rimexolone (1604600)Benzoyl Peroxide Impurity 9
Database identifiers
- CAS
49697-38-3- PubChem CID
- 39507
- ChEMBL
CHEMBL111461
Properties
Computed structural properties
- XLogP
- 3.5
- Topological polar surface area
- 54.4 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 2
- Heavy atoms
- 27
- Formal charge
- 0
- Complexity
- 749
Experimental & physicochemical properties
LogP4.2
Solubility1.21e-02 g/L
Physical DescriptionSolid
Physicochemical properties
- Melting point
- 258 · 258-268 ºC
- alpha
- 100 ° · D +100° (c = 0.92 in pyridine)
- Boiling point
- 507 · 507.0±50.0 °C(Predicted)
- Density
- 1.12 · 1.12
- pka
- 14.42 · 14.42±0.70(Predicted)
- InChIKey
- QTTRZHGPGKRAFB-OOKHYKNYSA-N
- FDA UNII
- 7 M2E4264D · O7M2E4264D
- ATC code
- 2 AB12,S01BA13 · H02AB12,S01BA13
- Symbol(GHS)
- 8 · GHS08
- Signal word
- Danger
- Hazard statements
- 360 · H360
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- hs_code
- 2937290000
- Signal word
- Danger
- Symbol(GHS)
- GHS08
- Hazard statements
- H360
- Precautionary statements
- P201-P280-P308+P313
Chemistry & industry
Pharmacology
Cellular LocationsCytoplasm
Applications
DescriptionRimexolone, an ophthalmic corticosteroid, was launched in 1995 in the U.S.A. for the treatment of postoperative inflammation following ocular surgery and anterior uveitis. Rimexolone has high corticoid receptor affinity and is a potent local antiinflammatory agent with minimal systemic effects and virtually no atrophogenic action in many animal models studied, unique among a wide range of topical steroids. Rapid onset, long duration of action plus a superior safety profile are characteristics of rimexolone. It was also approved in Europe for the treatment of rheumatoid arthritis and is currently in clinical trials for tendinitis and osteoarthritis.
UsesAnti-inflammatory (local).
General DescriptionRimexolone, 11β-hydroxy-16α,17α-dimethyl-17-(1-oxopropyl)androsta-1,4-diene-3-one,like medrysone and fluorometholone, lacks the C21 OHgroup. In addition, rimexolone has an additional methylgroup in the 17 -position, a site where an OH group is typicallyfound. Rimexolone is available as a suspension forophthalmic use.
Upstream & downstream products
Upstream raw materials
Suppliers26 total
国药集团化学试剂有限公司86-21-63210123 · [email protected]
Related reactions
0 records
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Compound notes
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