Tiamenidine Hydrochloride
Basic information
- CAS
51274-83-0- Standard SMILES
Cc1csc(Cl)c1NC1=NCCN1.Cl- InChIKey
RPZYVGSSBVNVCS-UHFFFAOYSA-N- Molecular formula
- C8H11Cl2N3S
- Average molar mass
- 252.16 g/mol
- Monoisotopic mass
- 251.0050739
Overview
See also: Tiamenidine (has active moiety).
Names & identifiers
- Preferred name
- Tiamenidine Hydrochloride
- IUPAC
- N-(2-chloro-4-methylthiophen-3-yl)-4,5-dihydro-1H-imidazol-2-amine;hydrochloride
- English name
- Tiamenidine hydrochloride
- Molecular formula
- C8H11Cl2N3S
- Molecular weight
- 252.16404
Names & synonyms
Tiamenidine hydrochlorideSymcorTiamenidine HCl51274-83-0SundralenThiamenidine hydrochlorideTiamenidine hydrochloride [USAN]EINECS 257-100-4UNII-9SE2T8DW90HOE 42-440Symcor (TN)9SE2T8DW90
Show more names
ThiamendineThiamenidine·hydrochloric acidN-(2-Chloro-4-methylthiophen-3-yl)-4,5-dihydro-1H-imidazol-2-amine hydrochlorideN-(2-chloro-4-methyl-3-thienyl)-4,5-dihydro-1H-imidazol-2-amine monohydrochloride
Hoe-42-440Tiamenidine hydrochloride (USAN)DTXSID701992732-((2-Chloro-4-methyl-3-thienyl)amino)-2-imidazoline hydrochloride2-(2'-Chloro-4'-methyl-3'-thienylamino)-1,3-diazacyclo-pent-2-ene hydrochlorideN-(2-Chloro-4-methyl-3-thienyl)-4,5-dihydro-1H-imidazol-2-amine hydrochlorideTIAMENIDINE HYDROCHLORIDE [MI]TIAMENIDINE HYDROCHLORIDE [MART.]
Database identifiers
- CAS
51274-83-0- PubChem CID
- 39973
- DTXSID
DTXSID70199273- ChEMBL
CHEMBL2107008- UNII
- 9SE2T8DW90
- EC Number
- 257-100-4
Properties
Computed structural properties
- Topological polar surface area
- 64.7 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 2
- Heavy atoms
- 14
- Formal charge
- 0
- Complexity
- 221
Physicochemical properties
- Melting point
- 228 · 228-229°
- FDA UNII
- 9 SE2T8DW90 · 9SE2T8DW90
- Toxicity
- 50 in · LD50 in rats, mice (mg/kg): 40, 45 i.v.; in mice: 170 s.c., 400 orally (Lindner, Kaiser)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Toxicity
- LD50 in rats, mice (mg/kg): 40, 45 i.v.; in mice: 170 s.c., 400 orally (Lindner, Kaiser)
Chemistry & industry
Applications
DescriptionTiamenidine hydrochloride is a centrally-acting antihypertensive structurally related to clonidine. In patients with mild to moderate hypertension, tiamenidine exerts similar activity to clonidine, but with fewer sympathomimetic side-effects.
UsesSymcor(Hoechst-Roussel).
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Compound notes
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