Basic information
- CAS
52391-89-6- Standard SMILES
CN1C(=O)C(O)N=C(c2ccccc2F)c2cc(Cl)ccc21- InChIKey
RMFYWNFETXNTIQ-UHFFFAOYSA-N- Molecular formula
- C16H12ClFN2O2
- Average molar mass
- 318.73 g/mol
- Monoisotopic mass
- 318.0571335
Overview
Flutemazepam is a benzodiazepine.
Names & identifiers
- Preferred name
- 7-Chloro-1,3-dihydro-1-methyl-3-hydroxy-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one
- IUPAC
- 7-chloro-5-(2-fluorophenyl)-3-hydroxy-1-methyl-3H-1,4-benzodiazepin-2-one
- English name
- 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one
- Molecular formula
- C16H12ClFN2O2
- Molecular weight
- 318.73
Names & synonyms
7-Chloro-1,3-dihydro-1-methyl-3-hydroxy-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-oneRefChem:141067FLUTEMAZEPAM52391-89-6Flutemazepam [INN]Sas-6467-chloro-5-(2-fluorophenyl)-3-hydroxy-1-methyl-3H-1,4-benzodiazepin-2-one7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-oneJ8U5694BCW7-Chloro-5-(o-fluorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-oneFlutemazepamumFlutemazepamum [Latin]
Show more names
1-Methyl-3-hydroxy-5-(2-fluorophenyl)-7-chloro-1H-1,4-benzodiazepine-2(3H)-one1,3-Dihydro-7-chloro-5-(2-fluorophenyl)-3-hydroxy-1-methyl-2H-1,4-benzodiazepin-2-one2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-7-chloro-5-(2-fluoro-phenyl)-3-hydroxy-1-methyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one
EINECS 257-892-1Sas 646BRN 0688457UNII-J8U5694BCWFLUTEMAZEPAM [MART.]FLUTEMAZEPAM [WHO-DD]CHEMBL291770orb2815649
Properties
Computed structural properties
- XLogP
- 2.3
- Topological polar surface area
- 52.9 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 1
- Heavy atoms
- 22
- Formal charge
- 0
- Complexity
- 473
Experimental & physicochemical properties
LogP2.09
Physicochemical properties
- Melting point
- 162 · 162-164 °C(Solv: cyclohexane (110-82-7))
- Boiling point
- 550.3 · 550.3±50.0 °C(Predicted)
- Density
- 1.4 · 1.40±0.1 g/cm3(Predicted)
- pka
- 11.58 · 11.58±0.40(Predicted)
- FDA UNII
- 8 U5694BCW · J8U5694BCW
Chemistry & industry
Applications
UsesFlutemazepam-13C,d3, is the labeled analogue of Flutemazepam (F599410), an analogue of Temazepam (T017200), that has hypnotic, sedative, amnesiac, anxiolytic, anticonvulsant and skeletal muscle relaxant properties. Flutemazepam has been shown to have similiar propertis to Temazepam, and it is found to be effective for the treatment of severe states of anxiety, panic attacks, and severe insomnia.
Suppliers9 total
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
Zhejiang J&C Biological Technology Co.,Limited+1-2135480471 · [email protected]
TargetMol 中国（陶术生物）400-821-0310 15002144251 · [email protected]
PT CHEM GROUP LIMITED+86-85511178; +86-85511178 · [email protected]
艾吉析科技（上海）有限公司17717235263 17717235263 · [email protected]
Henan Bao Enluo International TradeCo.，LTD+86-17331933971 · [email protected]
杭州洁汉化工有限公司+86-571-86217390; +8618058761490 · [email protected]
上海瀚香生物科技有限公司17754423994 · [email protected]
Wuhan Han Sheng New Material Technology Co.，Ltd+86-17798174412 · [email protected]
Additional notes
Related reactions
3 records
Compound notes
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