Basic information
- CAS
6385-02-0- Standard SMILES
Cc1ccc(Cl)c(Nc2ccccc2C(=O)[O-])c1Cl- InChIKey
SBDNJUWAMKYJOX-UHFFFAOYSA-M- Molecular formula
- C14H10Cl2NO2-
- Average molar mass
- 295.1 g/mol
- Monoisotopic mass
- 294.0088589
Overview
Meclofenamic acid(1-) is a monocarboxylic acid anion resulting from the removal of the proton from the carboxy group of meclofenamic acid. The major species at pH 7.3. It is a conjugate base of a meclofenamic acid.
Names & identifiers
- Preferred name
- 2-[(2,6-Dichloro-3-methylphenyl)amino]benzoate
- IUPAC
- 2-(2,6-dichloro-3-methylanilino)benzoate
- English name
- MECLOFENAMATE SODIUM
- Molecular formula
- C14H10Cl2NO2.Na
- Molecular weight
- 318.13
Names & synonyms
meclofenamic acid(1-)2-(2,6-dichloro-3-methylanilino)benzoateCHEMBL876CB1 antagonist, BayerUPCMLD-DP0122-[(2,6-dichloro-3-methylphenyl)amino]benzoateUPCMLD-DP012:001CHEBI:76230BDBM50012896NSC755402CCG-204812NSC-755402
Show more names
Meclofenamateci583C02996MovensmeclomenMeclonaxsodiummeclophenamateSODIUM MECLOFENAMATEMECLOFENAMATE SODIUMMECLOFENAMATESODIUM,USP
NCGC00023217-03NCGC00023217-04NCGC00023217-05NCGC00023217-06NCGC00023217-12AB00053494AB00053494_19Q27145824
Database identifiers
- CAS
6385-02-0- PubChem CID
- 4036
- ChEMBL
CHEMBL876- ChEBI
CHEBI:76230
Properties
Computed structural properties
- XLogP
- 5.8
- Topological polar surface area
- 52.2 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 2
- Heavy atoms
- 19
- Formal charge
- -1
- Complexity
- 321
Physicochemical properties
- Melting point
- 287 · 287-291 °C
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- White solid.
- color
- White to Off-White
- biological source
- synthetic (organic)
- Water Solubility
- 50 mg/ml · Soluble in water at 50mg/ml. Also soluble in DMF, DMSO or ethanol
- Merck
- 14 · 14,5779
- Stability
- Hygroscopic
- Major Application
- pharmaceutical
- InChI
- 1S/C14H11Cl2NO2.Na.H/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19;;/h2-7,17H,1H3,(H,18,19);;
- InChIKey
- CHGIZYUDGOIAFY-UHFFFAOYSA-N
- SMILES
- [Na].Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl
- FDA UNII
- 9 MMQ0YER4E · 9MMQ0YER4E
- NCI Drug Dictionary
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
- rtecs
- CB2975500
- hs_code
- 2922498050
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H302
- Precautionary statements
- P280-P305+P351+P338
Chemistry & industry
Applications
DescriptionMeclofenamate is a time-dependent, non-specific competitive inhibitor of COX-1 and -2. The IC50 values for inhibition of human recombinant COX-1 and -2 are 1.5 and 9.7 μM, respectively for instantaneous inhibition. However, the IC50 is much lower if pre-incubated with the enzyme.
Usesantiinflammatory, antipyretic
UsesMeclofenamate Sodium is an NSAID used in the treatment of chronic pain.
General DescriptionMeclofenamate sodium (Meclomen) is available for use inthe treatment of acute and chronic RA, OA, and primarydysmenorrhea. It is metabolized in a similar manner tomefenamic acid discussed above, thus a similar restriction isalso applied to meclofenamate. The most significant side effectsare GI, including diarrhea.
Upstream & downstream products
Upstream raw materials
Suppliers68 total
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
湖南韵邦生物科技股份有限公司0731-88532326 13319508186 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
成都彼样生物科技有限公司18108052721 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…