Basic information
- CAS
2038-03-1- Standard SMILES
NCCN1CCOCC1- InChIKey
RWIVICVCHVMHMU-UHFFFAOYSA-N- Molecular formula
- C6H14N2O
- Average molar mass
- 130.19 g/mol
- Monoisotopic mass
- 130.11061307
Overview
4-2-Aminoethyl-morpholine is a member of morpholines.
Names & identifiers
- Preferred name
- 2-Morpholinoethylamine
- IUPAC
- 2-morpholin-4-ylethanamine
- English name
- 4-(2-Aminoethyl)morpholine
- Molecular formula
- C6H14N2O
- Molecular weight
- 130.19
Names & synonyms
4-(2-Aminoethyl)morpholine2038-03-14-Morpholineethanamine2-MorpholinoethylamineN-Aminoethylmorpholine2-(Morpholin-4-Yl)Ethan-1-AmineN-2-Aminoethylmorpholine2-(4-Morpholinyl)ethanaminebeta-Aminoaethyl-morpholinbeta-Aminoaethyl-morpholin [German]DTXSID4044408N-(Aminoethyl)morpholine
Show more names
2-morpholinoethan-1-amineMorpholinoethylamine2-morpholin-4-ylethanamine2-(4-Morpholinyl)ethylamineMorpholine, 4-(2-aminoethyl)-RARECHEM AL BW 0412LM11A 31 Impurity 12-Morpholinoethylami
BRN 0104378T92F2H779P2-morpholino-1-ethanamineAI3-522731-(2-aminoethyl)morpholine2-(4-morpholino)ethylamineEINECS 218-011-6UNII-T92F2H779P
Database identifiers
- CAS
2038-03-1- PubChem CID
- 408285
- DTXSID
DTXSID4044408- ChEMBL
CHEMBL214205- ChEBI
CHEBI:194580- UNII
- T92F2H779P
- EC Number
- 218-011-6
- Nikkaji
- J48.664G
Properties
Computed structural properties
- XLogP
- -1.1
- Topological polar surface area
- 38.5 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 2
- Heavy atoms
- 9
- Formal charge
- 0
- Complexity
- 71.5
Experimental & physicochemical properties
DrugsPharmaceuticals -> Listed in ZINC15
SpringerMaterials PropertiesOptical coefficient
Physicochemical properties
- Melting point
- 24 °C · 24 °C
- Boiling point
- 205 °C · 205 °C(lit.)
- Density
- 0.992 g/mL · 0.992 g/mL at 25 °C(lit.)
- refractive index
- 20 · n20/D 1.476(lit.)
- Flash point
- 347 °F · 347 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Chloroform, Methanol
- form
- Liquid After Melting
- pka
- 1 · pK1: 4.06(+2);pK2: 9.15(+1) (25°C)
- color
- Clear colorless to pale yellow
- Water Solubility
- soluble
- Sensitive
- Air Sensitive
- BRN
- 104378 · 104378
- Stability
- Air Sensitive
- InChI
- 1S/C6H14N2O/c7-1-2-8-3-5-9-6-4-8/h1-7H2
- InChIKey
- RWIVICVCHVMHMU-UHFFFAOYSA-N
- SMILES
- NCCN1CCOCC1
- CAS DataBase Reference
- 2038 · 2038-03-1(CAS DataBase Reference)
- EWG's Food Scores
- 1 · 1
- FDA UNII
- 92 F2H779P · T92F2H779P
- NIST Chemistry Reference
- 4 · 4-Morpholineethanamine(2038-03-1)
- EPA Substance Registry System
- 4 · 4-Morpholineethanamine (2038-03-1)
- UNSPSC Code
- 12352100 · 12352100
- NACRES
- 22 · NA.22
- Symbol(GHS)
- 5 · GHS05,GHS07
- Signal word
- Danger
- Hazard statements
- 302 · H302-H314-H317
- Precautionary statements
- 260 · P260-P270-P280-P301+P312-P303+P361+P353-P305+P351+P338
- PPE
- 3 · Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
- Hazard Codes
- C,T
- Risk Statements
- 22 · 22-34-43-24-40-23/24/25
- Safety Statements
- 26 · 26-36/37/39-45-22
- RIDADR
- 2735 · UN 2735 8/PG 2
- WGK Germany
- 2 · 2
- RTECS
- 7350000 · QD7350000
- Hazard Note
- Toxic
- TSCA
- TSCA listed
- HazardClass
- 8 · 8
- PackingGroup
- III
- HS Code
- 29349990 · 29349990
- Storage Class
- 8 A · 8A - Combustible corrosive hazardous materials
- Hazard Classifications
- 4 OralSkin · Acute Tox. 4 OralSkin Corr. 1BSkin Sens. 1
- Toxicity
- 50 · guinea pig,LD50,skin,300uL/kg (0.3mL/kg),Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 269, 1944.
- REACH Registrations
- Active
Safety & regulation
GHS classification
GHS Classification
Danger
H302 (98.3%): Harmful if swallowed [Warning Acute toxicity, oral]
P260, P261, P262, P264, P264+P265, P270, P272, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P333+P317, P361+P364, P362+P364, P363, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 60 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information
Status: Active Update: 07-09-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/19740
N-(2-Aminoethyl) morpholine: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesAcute Tox. 4 (98.3%)
Safety data
- PPE
- Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
- wgk
- 2
- tsca
- TSCA listed
- rtecs
- QD7350000
- ridadr
- UN 2735 8/PG 2
- hs_code
- 29349990
- Toxicity
- guinea pig,LD50,skin,300uL/kg (0.3mL/kg),Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 269, 1944.
- risk_code
- 22-34-43-24-40-23/24/25
- Signal word
- Danger
- Symbol(GHS)
- GHS05,GHS07
- hazard_code
- C,T
- hazard_note
- Toxic
- safety_code
- 26-36/37/39-45-22
- hazard_class
- 8
- Storage Class
- 8A - Combustible corrosive hazardous materials
- packing_group
- III
- Hazard statements
- H302-H314-H317
- REACH Registrations
- Active
- Hazard Classifications
- Acute Tox. 4 OralSkin Corr. 1BSkin Sens. 1
- Precautionary statements
- P260-P270-P280-P301+P312-P303+P361+P353-P305+P351+P338
Chemistry & industry
Uses & manufacturing
General Manufacturing Information4-Morpholineethanamine: ACTIVE
Applications
Uses4-(2-Aminoethyl)morpholine is used as a ligand and reacts with nickel(II) nitrite to form trans-bis[4-(2-aminoethyl)morpholine]dinitronickel(II).
Uses4-(2-Aminoethyl)morpholine is widely used in biomedical applications as this moiety serves as an important lysosome-targeting group. Some of its applications include:Synthesis of the lysosome-targetable fluorescent probe for hydrogen sulfide imaging in living cells.Synthesis of 1,8-naphthalimide conjugated Troger′s bases as deoxyribonucleic acid (DNA) targeting fluorescent probe.Synthesis of intramolecular charge transfer-photoinduced electron transfer-fluorescence resonance energy transfer (ICT-PET-FRET) fluorescent probe for monitoring pH changes in living cells.It is also used as a precursor to synthesize a variety of antimicrobial agents.
Upstream & downstream products
Upstream raw materials
Downstream products
Suppliers100 total
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
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Additional notes
DefinitionChEBI: 4-2-Aminoethyl-morpholine is a member of morpholines.
Related reactions
840 records
Compound notes
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