Efo-dine
PVP-I · polyvinyl · POLYVINYLPYRROLIDONE IODINE · betadine · PVP-IODINE · iodopovidone · inadine · disadined.p.
Identifiers & Physical Properties
| CAS No. | 25655-41-8 |
|---|---|
| Molecular formula | C6H9I2NO |
| Average molar mass | 364.95 g/mol |
| SMILES | C=CN1CCCC1=O.II |
| InChIKey | FAAHNQAYWKTLFD-UHFFFAOYSA-N |
| PubChem CID | 410087 |
| ChEMBL | CHEMBL5424182 |
Chemical & Physical Properties
| Topological polar surface area | 20.3 |
|---|---|
| Hydrogen bond donors | 0 |
| Hydrogen bond acceptors | 1 |
| Rotatable bonds | 1 |
| Heavy atoms | 10 |
| Formal charge | 0 |
| Complexity | 120 |
| Melting point | 300 °C |
| Storage conditions | Keep in dark place,Inert atmosphere,Room temperature |
| Solubility | H2O: soluble100mg/mLSoluble in water, ethyl alcohol, isopropyl alcohol, polyethylene glycol and glycerol. Insoluble in chloroform, carbon tetrachloride, hexane, acetone and petroleum ether. |
| Physical state | Powder |
| Color | Yellow-brown |
| Odor | ylsh. brn. amorphous powd., sl. char. odor |
| Merck | 13,7784 |
| Cosmetics Ingredients Functions | ANTIMICROBIAL |
| InChI | InChI=1S/C6H9NO.I2/c1-2-7-5-3-4-6(7)81-2/h2H,1,3-5H2 |
| InChIKey | FAAHNQAYWKTLFD-UHFFFAOYSA-N |
| SMILES | II.C(N1CCCC1=O)=C |
| CAS DataBase Reference | 25655-41-8(CAS DataBase Reference) |
| FDA 21 CFR | 310.545 |
| EWG's Food Scores | 1-3 |
| FDA UNII | 85H0HZU99M |
| NCI Drug Dictionary | Betadine |
| ATC code | D08AG02,D09AA09,D11AC06,G01AX11,R02AA15,S01AX18 |
| EPA Substance Registry System | Povidone-iodine (25655-41-8) |
| UNSPSC Code | 51102829 |
| NACRES | NA.85 |
| GHS pictogram | GHS05,GHS09 |
| Signal word | Danger |
| GHS hazard statements | H315-H318-H411 |
| GHS precautionary statements | P264-P273-P280-P302+P352-P305+P351+P338-P332+P313 |
| Personal protective equipment (PPE) | Eyeshields, Gloves, type N95 (US) |
| Safety statements (S) | 24/25-22 |
| Water hazard class (WGK) | 2 |
| RTECS number | TR1579600 |
| TSCA inventory status | TSCA listed |
| Customs code | 29339900 |
| Storage class | 11 - Combustible Solids |
| Hazard class | Aquatic Chronic 2Eye Dam. 1Skin Irrit. 2 |
| Hazardous substances data | 25655-41-8(Hazardous Substances Data) |
Safety & Regulations
| Personal protective equipment (PPE) | Eyeshields, Gloves, type N95 (US) |
|---|---|
| Water hazard class (WGK) | 2 |
| TSCA inventory status | TSCA listed |
| RTECS number | TR1579600 |
| Customs code | 29339900 |
| Signal word | Danger |
| GHS pictogram | GHS05,GHS09 |
| Safety statements (S) | 24/25-22 |
| Storage class | 11 - Combustible Solids |
| GHS hazard statements | H315-H318-H411 |
| Hazard class | Aquatic Chronic 2Eye Dam. 1Skin Irrit. 2 |
| GHS precautionary statements | P264-P273-P280-P302+P352-P305+P351+P338-P332+P313 |
| Hazardous substances data | 25655-41-8(Hazardous Substances Data) |
Applications & Uses
Uses
povidone iodine has bactericidal effect like iodine. It can be used as disinfectant and bacteriostatic agent in the medicine for anti-septic purposes for eye drops, nasal drops, and cream agents. It can also be made into disinfectant. povidone iodine is mainly used for the skin disinfection and equipment disinfection in hospital surgery and injections as well as prevention of infection in the field of stomatology, gynecology, surgery, and dermatology; it can also be used for disinfection of household utensils and appliances; for food industry and aquaculture industry, it is used for disinfection and animal disease control. It is the preferred international and domestic choice of medical iodine-contained fungicides and disinfectants for epidemic prevention. povidone iodine is a kind of iodine carrier, the so-called “tamed iodine”. Because this product can gradually release iodine to exert an antibacterial effect; its mechanism of action is through causing the protein denaturation and further death of bacteria. It is effective in treating bacteria, fungi, as well as viruses with a relative small tissue irritation effect.
Description
Povidone iodine is iodophor, used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol. A 10% povidone iodine solution contains 1% available iodine, but free-iodine is at 0.1% concentration. Skin exposure causes irritant rather than allergic contact dermatitis. In such a situation, however, iodine seems to be the true hapten.
History
Povidone iodine (PI) is frequently used during surgical preparation, postoperative wound cleaning and dressing. It was described by Shelaski about seventy years ago (Shelanski and Shelanski, 1956). PI consists of the complex structure of povidone, a polymer that is structurally similar to plasma proteins, and the iodine element, which has antimicrobial properties. The function of polyvinylpyrrolidone (PVP) used as a polymer includes increasing iodine solubility and penetration, decreasing iodine ion concentration and keeping iodine bound. However, PVP does not have antimicrobial properties. Shelanski defined this complex structure as 'iodophor' (Shelanski and Shelanski, 1956).
Preparation & Synthesis
Preparation
Povidone Iodine Solution is an antiseptic and disinfectant agent. The preparation method of povidone iodine: be that 1.17% potassium iodide is dissolved in part water in 10% water by mass percent, 2.34% iodine is added to wherein stirring and dissolving, be mixed with iodine solution standby; 0.01% stability auxiliary agent is dissolved in part water 10% water standby; In complex reaction still, add remaining water, open and stir, dropping into 10.0% polyvinylpyrrolidone k30 dissolves, then substep adds above-mentioned two kinds of solution that prepare, finally add 7.5% solvent normal propyl alcohol, after feeding intake, allow reactant mixture at 20 ℃, react 2 hours, react complete mixture is lowered the temperature and obtained betagen solution.