CAS 54143-56-5 Flecainide Acetate (HCID 41022)

Substructure search Find similar structures

Basic information

CAS: 54143-56-5
Standard SMILES: CC(=O)O.O=C(NCC1CCCCN1)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F
InChIKey: RKXNZRPQSOPPRN-UHFFFAOYSA-N
Molecular formula: C19H24F6N2O5
Average molar mass: 474.4 g/mol
Monoisotopic mass: 474.15894119

Overview

Flecainide acetate is an acetate salt obtained by combining flecainide with one molar equivalent of acetic acid. An antiarrhythmic agent used to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart). It has a role as an anti-arrhythmia drug. It contains a flecainide(1+).

Names & identifiers

Preferred name: Flecainide Acetate
IUPAC: acetic acid;N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide

Names & synonyms

Flecainide acetate54143-56-5FLECAINIDE MONOACETATER-818R 818DTXSID8020626M8U465Q1WQBenzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-, monoacetateDTXCID80626CHEBI:5091NSC719273RefChem:56567

Show more names

Flecainide Acetate TabletN-((2RS)-Piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide monoacetateTambocorFlecainide (acetate)MFCD00214290N-(2-Piperidylmethyl)-2,5-bis-(2,2,2-trifluoroethoxy)benzamide acetaten-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide acetateMLS000069675

Database identifiers

CAS: 54143-56-5
PubChem CID: 41022
DTXSID: DTXSID8020626
ChEMBL: CHEMBL1200822
ChEBI: CHEBI:5091
UNII: M8U465Q1WQ
EC Number: 258-997-5

Properties

Computed structural propertiesFilling in

Topological polar surface area: 96.9 Å²
Hydrogen bond donors: 3
Hydrogen bond acceptors: 12
Rotatable bonds: 7
Heavy atoms: 32
Formal charge: 0
Complexity: 531

Experimental & physicochemical properties

Solubility>71.2 [ug/mL] (The mean of the results at pH 7.4)

Human Drugs · 2 items

FDA approved drugs -> Active ingredient

Safety & regulation

GHS classification

GHS Classification · 4 items

Danger

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P203, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 47 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory InformationFlecainide acetate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Hazard Classes and CategoriesAcute Tox. 4 (100%)

Toxicology

Drug Induced Liver Injury · 6 items

Drug Induced Liver Injury Rank (DILIrank 2.0)

Flecainide acetate

vLess-DILI-concern

Adverse reactions

DOI:10.1016/j.drudis.2016.02.015

Chemistry & industry

Pharmacology

FDA Pharmacological Classification · 4 items

FLECAINIDE ACETATE

Antiarrhythmic [EPC]

FLECAINIDE ACETATE TABLET

Antiarrhythmic [EPC]

MeSH Pharmacological Classification · 2 items

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.

A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS.