HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-Methylhydroxylamine
Methoxyamine · NCI-C-60060 · (Aminooxy)methane · Relugoli Impurity 94 · O-methylhydroxylamine · ORTHO-METHYLHYDROXYLAMINE · Hydroxylamine, O-methyl- (8CI,9CI)
Identifiers & Physical Properties
| CAS No. | 67-62-9 |
|---|---|
| Molecular formula | CH5NO |
| Average molar mass | 47.057 g/mol |
| Monoisotopic mass | 47.03711378 g/mol |
| SMILES | CON |
| InChIKey | GMPKIPWJBDOURN-UHFFFAOYSA-N |
| PubChem CID | 4113 |
| ChEMBL | CHEMBL1213633 |
| ChEBI | CHEBI:192842 |
| EC No. | 200-660-1 |
| DTXSID | DTXSID8043862 |
Chemical & Physical Properties
| XLogP | -0.7 |
|---|---|
| Topological polar surface area | 35.3 |
| Hydrogen bond donors | 1 |
| Hydrogen bond acceptors | 2 |
| Rotatable bonds | 0 |
| Heavy atoms | 3 |
| Formal charge | 0 |
| Complexity | 4.8 |
| Chemical classes | Nitrogen Compounds -> Hydroxylamines |
| SpringerMaterials Properties | Schoenflies notation |
| Odor | FISHY, AMINE ODOR |
| Color/Form | MOBILE LIQUID |
| Solubility | SLIGHTLY SOL IN BENZENE, PETROLEUM ETHER /N-METHYLHYDROXYLAMINE/MISCIBLE WITH WATER, ALCOHOL, ETHER |
| Boiling point | 49-50 °C @ 760 MM HG47.83°C |
| Vapor pressure | 291.0 [mmHg] |
| Physical Description | Colorless liquid with an unpleasant odor[Hawley] |
| Other Experimental Properties | INDEX OF REFRACTION: 1.4164 @ 20 °C/DMELTING POINT: 42 °C WITH RAPID HEATINGDENSITY: 1.0003 G/ML @ 20 °C/4 °C /N-METHYLHYDROXYLAMINE/ |
| Melting point | 25°C |
| Density | 0.9069 g/cm3 |
| Refractive index | 1.4164 (estimate) |
| pKa (acidity coefficient) | 12.5(at 25℃) |
| FDA UNII | 9TZH4WY30J |
| NCI Drug Dictionary | dapansutrile |
| GHS pictogram | GHS07,GHS05 |
| Signal word | Danger |
| GHS hazard statements | H318-H302+H312+H332-H314 |
| GHS precautionary statements | P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501-P280-P305+P351+P338-P310 |
| UN transport number | 1760 |
| Hazard class | 8 |
| Packing group | II |
| Hazardous substances data | 67-62-9(Hazardous Substances Data) |
Safety & Regulations
| GHS classification | DangerH302+H312+H332 (96.6%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oralacute toxicity, dermalacute toxicity, inhalation]P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 29 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Hazards summary | Highly irritating[Merck Index] A strong skin irritant[Hawley] Emergency treatment: Corrosives-alkaline[HSDB] Mutagenic[RTECS] See Hydroxylamine. |
| Hazard Classes and Categories | Acute Tox. 4 (100%) |
| Skin, Eye, and Respiratory Irritations | ...CORROSIVE TO SKIN & HIGHLY IRRITANT TO EYES & MUCOUS MEMBRANES... /HYDROXYLAMINE/ |
| Adverse effects | Dermatotoxin - Skin burns. |
| Human Toxicity Excerpts | ...CORROSIVE TO SKIN & HIGHLY IRRITANT TO EYES & MUCOUS MEMBRANES. REPEATED EXPOSURE MAY ENHANCE ALLERGIC REACTION PARTICULARLY OF BACK OF HANDS & FOREARMS FROM 1-2 WK TO 2-5 YR AFTER COMMENCEMENT OF EXPOSURE & CASES OF ECZEMA...FOLLOWING PROLONGED CONTACT. ... NO CASES OF SYSTEMIC POISONING...IN WORKERS. /HYDROXYLAMINE//HYDROXYLAMINE IS/ ABOUT EQUIPOTENT TO NITRITE AS METHEMOGLOBIN FORMER, BUT IT HAS GREATER TENDENCY TO PRODUCE SULFHEMOGLOBIN, HEINZ BODIES & OTHER IRREVERSIBLE RED CELL DAMAGE. ... SYSTEMIC POISONING CHARACTERIZED BY CYANOSIS, CONVULSIONS & COMA. /HYDROXYLAMINE/ |
| Non-Human Toxicity Excerpts | /HIGH CONCN/ IN ANIMALS...CAUSES CONVULSIONS FOLLOWED BY PARALYSIS & DEATH FROM CESSATION OF BREATHING... CHRONIC ABSORPTION OF MODERATE DOSES (1 MG/KG) MAY LEAD TO SLIGHT ANEMIA. /HYDROXYLAMINE/...INHIBITOR OF CATALASE &...WHEN ADMIN PARENTERALLY, 40 MG CAUSING CONVULSIONS, NYSTAGMUS & DEATH IN RABBIT. LOCAL APPLICATION OF 10% SOLN...TO RABBIT EYES...CAUSED MODERATE INFLAMMATION OF CONJUNCTIVA. /HYDROXYLAMINE/HYDROXYLAMINE ELEVATES BRAIN GABA /GAMMA-AMINOBUTYRIC ACID/ LEVELS IN RATS. /HYDROXYLAMINE/O-METHYLHYDROXYLAMINE (2000 MCG/ML) INDUCED RESISTANCE MUTATION TO 8-AZAGUANINE. IT IS HIGHLY POTENT MUTAGEN FOR MICROORGANISMS AS WELL AS FOR MAMMALIAN CELLS.REPLICATION OF PHAGE MS2 IN PRESENCE OF O-METHYLHYDROXYLAMINE (MUTAGENESIS IN VIVO) INCR REVERSION FREQUENCY OF 2 AMBER MUTATIONS IN MATURATION PROTEIN. PROBABLE MODE OF MUTAGENIC ACTION INVOLVES ENZYMATIC FORMATION OF MODIFIED PRECURSORS & INCORPORATION INTO RNA. |
| UN transport number | 1760 |
| Signal word | Danger |
| GHS pictogram | GHS07,GHS05 |
| Hazard class | 8 |
| Packing group | II |
| GHS hazard statements | H318-H302+H312+H332-H314 |
| GHS precautionary statements | P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501-P280-P305+P351+P338-P310 |
| Hazardous substances data | 67-62-9(Hazardous Substances Data) |
Applications & Uses
Uses
Analytical reagent, mainly for ketones and aldehydes.