Basic information
- CAS
93-30-1- Standard SMILES
CNC(C)Cc1ccccc1OC- InChIKey
OEHAYUOVELTAPG-UHFFFAOYSA-N- Molecular formula
- C11H17NO
- Average molar mass
- 179.26 g/mol
- Monoisotopic mass
- 179.13101417
Overview
Methoxyphenamine is an amphetamine methylated on nitrogen and with the phenyl ring methoxylated at C-2. A beta-adrenergic receptor agonist, it is used as a bronchodilator. It has a role as a beta-adrenergic agonist and a bronchodilator agent.
Names & identifiers
- Preferred name
- Methoxyphenamine
- IUPAC
- 1-(2-methoxyphenyl)-N-methylpropan-2-amine
- English name
- Methoxyphenamine
- Molecular formula
- C11H17NO
- Molecular weight
- 179.25878
Names & synonyms
METHOXYPHENAMINE93-30-12-MethoxymethamphetamineMethoxyphenaminummetoxifenaminaDTXSID0023292J3Z5SRI26Z[1-(2-methoxyphenyl)propan-2-yl](methyl)amineo-Methoxy-N,alpha-dimethylphenethylamine2-methoxy-N,alpha-dimethylphenethylamineDTXCID203292Benzeneethanamine, 2-methoxy-N,alpha-dimethyl-
Show more names
OrtoxineOrtodrinexMexyphamineMethoxyphenaminMethoxiphenadrinMethoxyphenadrineMethoxyphenamine-Mdl-Methoxyphenamine
CHEBI:134817(1-(2-methoxyphenyl)propan-2-yl)(methyl)amine(+-)-Methoxyphenamine1-(2-methoxyphenyl)-2-methylaminopropaneRefChem:811822R03CB02202-237-7Orthoxine
Database identifiers
- CAS
93-30-1- PubChem CID
- 4117
- DTXSID
DTXSID0023292
Properties
Computed structural properties
- XLogP
- 2.6
- Topological polar surface area
- 21.3 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 4
- Heavy atoms
- 13
- Formal charge
- 0
- Complexity
- 138
Experimental & physicochemical properties
Drugs
DEA NFLIS-Drug Category -> Phenethylamines (Amphetamines) (H)
Pharmaceuticals -> Synthetic Cannabinoids or Psychoactive Compounds
Melting Point< 25 °C
Physical DescriptionSolid
Dissociation Constants10.45
Physicochemical properties
- Melting point
- 271 ℃ · 271℃
- Boiling point
- 252 ℃ · 252℃
- Density
- 0.951 · 0.951
- Flash point
- 103 ℃ · 103℃
- pka
- 10.36 · 10.36±0.10(Predicted)
- FDA UNII
- 3 Z5SRI26Z · J3Z5SRI26Z
- REACH Registrations
- Active
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 66.7% (2 of 3) of all reports.
Warning
H302 (33.3%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 3 reports by companies from 2 notifications to the ECHA C&L Inventory.
Hazard information
Regulatory InformationREACH registered substance: Methoxyphenamine (EC: 202-237-7)
Hazard Classes and CategoriesAcute Tox. 4 (33.3%)
Safety data
- REACH Registrations
- Active
Chemistry & industry
Pharmacology
ATC Code
R - Respiratory system
QR - Respiratory system
MeSH Pharmacological ClassificationDrugs that selectively bind to and activate beta-adrenergic receptors.
Cellular LocationsMembrane
Applications
UsesMethoxyphenamine is an adrenaline-mimetic drug with significant bronchodilation and smooth muscle relaxation effects. It also has a mild antihistamine effect, a sedative effect and suppresses the cough center. It is suitable for treating bronchial asthma, especially for patients who cannot tolerate ephedrine.
Upstream & downstream products
Upstream raw materials
Suppliers11 total
Beckmann-Kenko GmbH+49 4241 9308 88 · [email protected]
宝鸡缔都医药化工有限公司029-81145305 17791533577 · [email protected]
武汉鹏胤药业有限公司13163333255 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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