6-Amino-o-cresol (HCID 413657)

Names & identifiers

Preferred name: 6-Amino-o-cresol
IUPAC: 2-amino-6-methylphenol
English name: 6-Amino-2-methylphenol
Molecular formula: C7H9NO
Molecular weight: 123.15

Names & synonyms

2-amino-6-methylphenol17672-22-96-Amino-2-methylphenol6-Amino-o-cresolPhenol, 2-amino-6-methyl-o-Cresol, 6-amino-6-Methyl-2-aminophenol6-Methyl-o-aminophenolUNII-4N899ESJ5B6-Amino-o-cresol [INCI]4N899ESJ5BDTXSID80170179

Show more names

2-methyl-6-aminophenol6- aMinocresolASISCHEM D509546-AMINO-ORTHO-CRESOL2-Amino-6-methylpheno6-Amino-o-methylphenol6-AMINO-O-CRESOL, 99.5%

2A6MP6-Amino-o-creosolRefChem:104199DTXCID9092670605-780-12-Amino-6-methyl-phenolMFCD03788432Amino-hydroxy-methyl-benzol

Database identifiers

CAS: 17672-22-9
PubChem CID: 413657
DTXSID: DTXSID80170179
ChEMBL: CHEMBL5542658
UNII: 4N899ESJ5B
EC Number: 605-780-1
Nikkaji: J1.712.101D

Properties

Computed structural properties

XLogP: 1.5
Topological polar surface area: 46.3 Å²
Hydrogen bond donors: 2
Hydrogen bond acceptors: 2
Rotatable bonds: 0
Heavy atoms: 9
Formal charge: 0
Complexity: 94

Physicochemical properties

Melting point: 86 ℃ · 86℃
Boiling point: 232.9 · 232.9±28.0 °C(Predicted)
Density: 1.157 · 1.157±0.06 g/cm3(Predicted)
storage temp.: 2 · 2-8°C(protect from light)
pka: 10.1 · 10.10±0.10(Predicted)
Appearance: Brown to reddish brown Solid
Cosmetics Ingredients Functions: HAIR DYEING
Cosmetic Ingredient Review (CIR): 6 · 6-Amino-2-methylphenol (17672-22-9)
InChI: 1S/C7H9NO/c1-5-3-2-4-6(8)7(5)9/h2-4,9H,8H2,1H3
InChIKey: ALQKEYVDQYGZDN-UHFFFAOYSA-N
SMILES: Cc1cccc(N)c1O
CAS DataBase Reference: 17672 · 17672-22-9
EWG's Food Scores: 3 · 3-6
FDA UNII: 4 N899ESJ5B · 4N899ESJ5B
UNSPSC Code: 12352200 · 12352200
Symbol(GHS): 5 · GHS05
Signal word: Warning
Hazard statements: 314 · H314
Precautionary statements: 264 b-P271-P280-P301+P330+P331-P304+P340-P305+P351+P338-P310-P363-P403+P233-P501c · P264b-P271-P280-P301+P330+P331-P304+P340-P305+P351+P338-P310-P363-P403+P233-P501c
target organs: Respiratory system
Hazard Codes: Xn
Risk Statements: 22 · 22-36/37/38
Safety Statements: 26 · 26
WGK Germany: 3 · WGK 3
HazardClass: IRRITANT
HS Code: 29222990 · 29222990
Storage Class: 11 · 11 - Combustible Solids
Hazard Classifications: 4 OralEye · Acute Tox. 4 OralEye Irrit. 2Skin Irrit. 2STOT SE 3

Safety & regulation

GHS classification

GHS Classification · 5 items

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]；H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Regulatory InformationChemical: Phenol, 2-amino-6-methyl-

Other Safety InformationIMAP assessments - Chemicals with limited data availability that may be used in hair dyes overseas: Human health tier II assessment；IMAP assessments - Phenol, 2-amino-6-methyl-: Environment tier I assessment

Hazard Classes and CategoriesAcute Tox. 4 (100%)；Skin Irrit. 2 (100%)；Eye Irrit. 2A (100%)；STOT SE 3 (100%)

Toxicology

Toxicity Summary · 2 items

The Expert Panel for Cosmetic Ingredient Safety concluded that the available data are insufficient to make a determination of safety for 6-Amino-o-Cresol under the intended conditions of use as a hair dye ingredient.

Safe for use in cosmetics, with qualifications

Regulatory information

Regulatory InformationChemical: Phenol, 2-amino-6-methyl-

Safety data

wgk: WGK 3
hs_code: 29222990
risk_code: 22-36/37/38
Signal word: Warning
Symbol(GHS): GHS05
hazard_code: Xn
safety_code: 26
hazard_class: IRRITANT
Storage Class: 11 - Combustible Solids
target organs: Respiratory system
Hazard statements: H314
Hazard Classifications: Acute Tox. 4 OralEye Irrit. 2Skin Irrit. 2STOT SE 3
Precautionary statements: P264b-P271-P280-P301+P330+P331-P304+P340-P305+P351+P338-P310-P363-P403+P233-P501c

Chemistry & industry

Uses & manufacturing

UsesCIR ingredient: 6-Amino-o-Cresol

Use ClassificationCosmetics -> Hair dyeing

Applications · 1 item

Uses6-Amino-2-methylphenol is a colorant that has been classified as a skin sensitizer. It is used in the manufacture of inorganic pigments and other organic compounds, such as dyes and paints. 6-Amino-2-methylphenol absorbs ultraviolet radiation and reacts with chloride to form 2-amino, 6-(chloromethyl) phenol, which has been shown to have subchronic toxicity. This chemical also photodegrades in sunlight, producing free radicals that can damage cells.