Basic information
- CAS
55294-15-0- Standard SMILES
CC(c1ccc(Cl)c(Cl)c1)N1N=C(N)CC1=O- InChIKey
RLWRMIYXDPXIEX-UHFFFAOYSA-N- Molecular formula
- C11H11Cl2N3O
- Average molar mass
- 272.13 g/mol
- Monoisotopic mass
- 271.0279174
Overview
Muzolimine is a dichlorobenzene.
Names & identifiers
- Preferred name
- Muzolimine
- IUPAC
- 5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-4H-pyrazol-3-one
- English name
- Muzolimine
- Molecular formula
- C11H11Cl2N3O
- Molecular weight
- 272.13
Names & synonyms
MUZOLIMINE55294-15-0EdrulMuzoliminaBay-g-2821BAY G 2821MuzoliminumBAY-G 282107Z36289ZX3-amino-1-[1-(3,4-dichlorophenyl)ethyl]-4,5-dihydro-1H-pyrazol-5-one3H-Pyrazol-3-one, 5-amino-2-(1-(3,4-dichlorophenyl)ethyl)-2,4-dihydro-3H-Pyrazol-3-one, 5-amino-2-[1-(3,4-dichlorophenyl)ethyl]-2,4-dihydro-
Show more names
3-Amino-1-(3,4-dichloro-α-methylbenzyl)-2-pyrazolin-5-one3-amino-1-(1-(3,4-dichlorophenyl)ethyl)-1H-pyrazol-5(4H)-one
3-amino-1-(1-(3,4-dichlorophenyl)ethyl)-4,5-dihydro-1H-pyrazol-5-oneRefChem:389134G 2821, BayC03CD01259-573-25-amino-2-[1-(3,4-dichlorophenyl)ethyl]-4H-pyrazol-3-one3-Amino-1-(3,4-dichloro-alpha-methylbenzyl)-2-pyrazolin-5-oneBAY-g 2821; Edrul
Database identifiers
- CAS
55294-15-0- PubChem CID
- 41386
- DTXSID
DTXSID50866476- ChEMBL
CHEMBL1697760
Properties
Computed structural properties
- XLogP
- 2
- Topological polar surface area
- 58.7 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 2
- Heavy atoms
- 17
- Formal charge
- 0
- Complexity
- 348
Physicochemical properties
- Melting point
- 127 · 127-129°
- Boiling point
- 401.4 · 401.4±55.0 °C(Predicted)
- Density
- 1.5374 · 1.5374 (rough estimate)
- refractive index
- 1.55 · 1.5500 (estimate)
- pka
- 3.3 · 3.30±0.50(Predicted)
- form
- Solid
- color
- Light yellow to yellow
- FDA UNII
- 7 Z36289ZX · 07Z36289ZX
- ATC code
- 3 CD01 · C03CD01
- Toxicity
- 50 in · LD50 in mice, rats, dogs, rabbits (mg/kg): 1794, 1559, 2000, 1250 orally (Lorke, Mürmann)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Toxicity
- LD50 in mice, rats, dogs, rabbits (mg/kg): 1794, 1559, 2000, 1250 orally (Lorke, Mürmann)
Chemistry & industry
Pharmacology
ATC Code
C - Cardiovascular system
QC - Cardiovascular system
MeSH Pharmacological Classification
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Agents that promote the excretion of urine through their effects on kidney function.
Applications
DescriptionMuzolimine is a structurally novel, pyrazolone diuretic with a high-ceiling profile. It is somewhat slower in onset than furosemide, but has a more prolonged effect, similar to the thiazides. Muzolimine has been shown to be effective in edema of cardiac, hepatic and renal origin. It also appears to be effective as an antihypertensive agent.
UsesDiuretic; antihypertensive.
Suppliers11 total
Sinoway Industrial co., ltd.+86-0592-5800732 +86-13806035118 · [email protected]
武汉丰泰威远科技有限公司+86-27-8746-5837 +86-18627785180 · [email protected]
武汉丰泰威远科技有限公司027-87465837 19945049750 · [email protected]
BOC Sciences1-631-485-4226; 16314854226 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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