Basic information
- CAS
56488-59-6- Standard SMILES
CC(C)(C)c1ccc(OCC(O)COc2ccc(C(=O)O)cc2)cc1- InChIKey
PXODZCMXOZRVEN-UHFFFAOYSA-N- Molecular formula
- C20H24O5
- Average molar mass
- 344.4 g/mol
- Monoisotopic mass
- 344.16237386
Overview
Terbufibrol is an agent with antilipidemic activity. Animal studies show that terbufibrol is 10 times more active than clofibrate in reducing serum total cholesterol and suggest that it blocks hepatic cholesterol synthesis in a step between acetate and HMG-CoA.
Names & identifiers
- Preferred name
- Terbufibrol
- IUPAC
- 4-[3-(4-tert-butylphenoxy)-2-hydroxypropoxy]benzoic acid
- English name
- Terbufibrol
- Molecular formula
- C20H24O5
- Molecular weight
- 344.4
Names & synonyms
Terbufibrol56488-59-6TerbufibrolumW41Z308IA3p-(3-(p-tert-Butylphenoxy)-2-hydroxypropoxy)benzoic acidDTXSID60866568Benzoic acid, 4-(3-(4-(1,1-dimethylethyl)phenoxy)-2-hydroxypropoxy)-RefChem:187941DTXCID608148424-(3-(4-t-butylphenoxy)-2-hydroxypropoxy)benzoic acidTerbufibrol [INN]4-[3-(4-tert-butylphenoxy)-2-hydroxypropoxy]benzoic acid
Show more names
Reaxys ID: 2949416Terbufibrol, 10 mM in DMSOp-[3-(p-tert-Butylphenoxy)-2-hydroxypropoxy]benzoic acidp-[[3-(p-t-Butylphenoxy)-2-hydroxypropyl]oxy]benzoic acidBenzoic acid, 4-[3-[4-(1,1-dimethylethyl)phenoxy]-2-hydroxypropoxy]-
Terbufibrolum [INN-Latin]BRN 2949416UNII-W41Z308IA3Terbufibrol?K-11,2674'-(3-(4'-t-Butylphenoxy)-2-hydroxypropoxy)benzoic acid4-(3-(4-(1,1-Dimethylethyl)phenoxy)-2-hydroxypropoxy)benzoic acidK-11267
Database identifiers
- CAS
Properties
Computed structural properties
- XLogP
- 4.1
- Topological polar surface area
- 76 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 8
- Heavy atoms
- 25
- Formal charge
- 0
- Complexity
- 401
Physicochemical properties
- Boiling point
- 439.5 °C · 439.5°C (rough estimate)
- Density
- 1.1444 · 1.1444 (rough estimate)
- refractive index
- 1.54 · 1.5400 (estimate)
- storage temp.
- -20 °C · Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 4.41 · 4.41±0.10(Predicted)
- color
- White to off-white
- FDA UNII
- 41 Z308IA3 · W41Z308IA3
Chemistry & industry
Applications
UsesTerbufibrol has been shown highly active in reducing serum total cholesterol (TC) levels in the normal and hypercholesterolemic male rat.
Suppliers6 total
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
深圳市丽晶生化科技有限公司0755-85201366 18938635012 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354 · [email protected]
上海阿摩尔生物科技有限公司13370042665 18916960931 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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