4-(2-(2-Ethyl-5'-(6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl)-3'-methyl(2,2'-bioxolan)-5-yl)-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro(4.5)decan-7-yl)-3-methoxy-2-methylpentanoic acid

DescriptionMonensin is a naturally occuring ionophorous antibiotic that preferentially forms complexes with monovalent cations to enable transport across lipid membranes. Through its ability to affect pH and the sodium-potassium balance of a cell, monensin can induce cell death in Gram-positive bacteria such as Micrococcus, Bacillus, and Staphylococcus (MICs = 1-12.5 μg/ml), reduce proliferation of P. falciparum and Coccicdium protozoa, and also prevent replication of certain viruses.

UsesPoliether antibiotic. Coccidiostat.

Usesantifungal

Usesantibacterial

UsesMonensin sodium salt is used in potentiometric and spectroscopic studies of alkali metal ion complexes. Monensin (Na) is a polyether small molecule ionophore, capable of forming stable complexes to monovalent cations with specific affinity for Na+. Monensin presents a highly lipophilic scaffold around the bound ion, allowing movement of the complex through the lipid bilayer and consequent transport of the ion out of the cell. Excessive flux of ions out of the cell produces a cytotoxic effect and generates the antibiotic properties of Monensin.

General DescriptionMonensin is a polyether ionophoric antibiotic, which is produced by Streptomyces cinnamonensis. It is used to treat bacterial, fungal and parasitic infections. Monensin prevents the growth of colon cancer cells. It facilitates the transport of sodium and potassium ions between intracellular and extracellular spaces. Monensin prevents coccidiosisin poultry production.