Mosapramine

HCID 4257

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Basic information

CAS: 89419-40-9
Standard SMILES: O=C1NC2CCCCN2C12CCN(CCCN1c3ccccc3CCc3ccc(Cl)cc31)CC2
InChIKey: PXUIZULXJVRBPC-UHFFFAOYSA-N
Molecular formula: C28H35ClN4O
Average molar mass: 479.1 g/mol
Monoisotopic mass: 478.2499394

Overview

Mosapramine is a racemate comprising equimolar amounts of (R)- and (S)-mosapramine. It is a second-generation antipsychotic used for the treatment of schizophrenia. It has a role as a dopaminergic antagonist and a second generation antipsychotic. It contains a (S)-mosapramine and a (R)-mosapramine.

Names & identifiers

Preferred name: Mosapramine
IUPAC: 1'-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]spiro[1,5,6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-3,4'-piperidine]-2-one
English name: Mosapramine
Molecular formula: C28H35ClN4O
Molecular weight: 479.06

Names & synonyms

Mosapramine89419-40-9ClospipramineMosapraminaDTXSID004884604UZQ7O9SJDTXCID7028772CHEBI:135775mosapraminum3-chloro-5-(3-(2-oxo-1,2,3,5,6,7,8,8a-octahydroimidazo(1,2-a)pyridine-3-spiro-4'-piperidino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepineRefChem:819536Spiro(imidazo(1,2-a)pyridine-3(2H),4'-piperidin)-2-one, 1'-(3-(3-chloro-10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl)hexahydro-, dihydrochloride

Show more names

MOSAPRAMINE USP/EP/BP5H-Dibenz[b,f]azepine, spiro[imidazo[1,2-a]pyridine-3(2H),4'-piperidin]-2-one deriv.1'-[3-[(3-Chloro-10,11-dihydro-5H-dibenz[b,f]azepin)-5-yl]propyl]hexahydrospiro[imidazo[1,2-a]pyridine-3(2H),4'-piperidin]-2-one(±)-1’-[3-(3-Chloro-10-11-dihydro-5H-dibenz[b，f]azepin-5-y1)propyl]hexahydrospim[irnidazo[1，2-α]pyridine-3(2H)，4'-piperidin]-2-oneSpiro[imidazo[1,2-a]pyridine-3(2H),4'-piperidin]-2-one, 1'-[3-(3-chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]hexahydro- (9CI)Spiro[imidazo[1,2-a]pyridine-3(2H),4'-piperidin]-2-one, 1'-[3-(3-chloro-10,11-dihydro-5H-dibenz[b,f]azepin-5-yl)propyl]hexahydro-, (+-)-

N05AX101'-(3-(14-chloro-2-azatricyclo(9.4.0.0^(3,8))pentadeca-1(11),3,5,7,12,14-hexaen-2-yl)propyl)-hexahydro-1H-spiro(imidazo(1,2-a)pyridine-3,4'-piperidin)-2-oneMosapramine [INN]Mosapramine (hydrochloride)Clospipramine (hydrochloride)1'-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]spiro[1,5,6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-3,4'-piperidine]-2-one1'-[3-(3-chloro-10,11-dihydro-5h-dibenzo[b,f]azepin-5-yl)propyl]hexahydro-2h-spiro[imidazo[1,2-a]pyridine-3,4'-piperidin]-2-oneMosapramine (INN)

Database identifiers

CAS: 89419-40-9
PubChem CID: 4257
DTXSID: DTXSID0048846
ChEMBL: CHEMBL2106650
ChEBI: CHEBI:135775
UNII: 04UZQ7O9SJ
Nikkaji: J260.514G

Properties

Computed structural properties

XLogP: 5.4
Topological polar surface area: 38.8 Å²
Hydrogen bond donors: 1
Hydrogen bond acceptors: 4
Rotatable bonds: 4
Heavy atoms: 34
Formal charge: 0
Complexity: 725

Physicochemical properties

Boiling point: 680.2 · 680.2±55.0 °C(Predicted)
Density: 1.26 g/cm3 · 1.26 g/cm3
pka: 14.9 · 14.90±0.20(Predicted)
FDA UNII: 4 UZQ7O9SJ · 04UZQ7O9SJ
ATC code: 5 AX10 · N05AX10

Chemistry & industry

Pharmacology

ATC Code · 2 items

N - Nervous system

QN - Nervous system

Applications

UsesMosapramine is a anti-psychotic as it is used in the treatment of schizophrenia.

Suppliers9 total

杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]

LGM Pharma1-(800)-881-8210 · [email protected]

湖北扬信医药科技有限公司0714-3999001 19171453112 · [email protected]

上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]

上海陶术生物科技股份有限公司13564774135 · [email protected]

Additional notes · 1 item

DefinitionChEBI: Mosapramine is a racemate comprising equimolar amounts of (R)- and (S)-mosapramine. It is a second-generation antipsychotic used for the treatment of schizophrenia. It has a role as a second generation antipsychotic and a dopaminergic antagonist. It contains a (S)-mosapramine and a (R)-mosapramine.

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