Basic information
- CAS
127502-06-1- Standard SMILES
CCOCCP(CCOCC)CCP(CCOCC)CCOCC- InChIKey
QCWJONLQSHEGEJ-UHFFFAOYSA-N- Molecular formula
- C18H40O4P2
- Average molar mass
- 382.5 g/mol
- Monoisotopic mass
- 382.24018375
Overview
Tetrofosmin is a phosphine.
Names & identifiers
- Preferred name
- Tetrofosmin
- IUPAC
- 2-[bis(2-ethoxyethyl)phosphanyl]ethyl-bis(2-ethoxyethyl)phosphane
- English name
- Tetrofosmin
- Molecular formula
- C18H40O4P2
- Molecular weight
- 382.46
Names & synonyms
TetrofosminUNII-3J0KPB596QtetrofosmineTetrofosmina3J0KPB596QP 53P-53DTXSID70155591TETROFOSMIN (II)TETROFOSMIN [II]tetrofosminumRefChem:58134
Show more names
Myoview
DTXCID5078082V09GA02127502-06-1ethylenebis[bis(2-ethoxyethyl)phosphine]2-[bis(2-ethoxyethyl)phosphanyl]ethyl-bis(2-ethoxyethyl)phosphane3,12-Dioxa-6,9-diphosphatetradecane, 6,9-bis(2-ethoxyethyl)-Tetrofosmin [USAN:INN:BAN:JAN]6,9-bis(2-ethoxyethyl)-3,12-dioxa-6,9-diphosphatetradecane
Database identifiers
- CAS
127502-06-1- PubChem CID
- 4274
- DTXSID
DTXSID70155591- ChEMBL
CHEMBL1615784- ChEBI
CHEBI:135598- UNII
- 3J0KPB596Q
- Nikkaji
- J506.542I
Properties
Computed structural properties
- XLogP
- 0.5
- Topological polar surface area
- 36.9 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 19
- Heavy atoms
- 24
- Formal charge
- 0
- Complexity
- 201
Experimental & physicochemical properties
DrugsPharmaceuticals -> Listed in ZINC15
SolubilitySoluble
Boiling Point100ºC
Physicochemical properties
- Boiling point
- 447.1 · 447.1±45.0 °C(Predicted)
- FDA UNII
- 3 J0KPB596Q · 3J0KPB596Q
Chemistry & industry
Pharmacology
Protein BindingRefer to [DB09160]
PharmacodynamicsRefer to [DB09160]
Mechanism of Action
Tetrofosmin normal biodistribution makes it suitable to be used as a myocardial agent as it is uptaken by the myocardial tissue and it presents a very low redistribution after 3-4 hours of administration. After distribution, tetrofosmin is a lipophilic cationic agent which is passively diffused and accumulated in viable myocardial tissue.
Biological Half-LifeRefer to [DB09160]
Metabolism/MetabolitesThis pharmacokinetic property has not been fully studied.
Absorption, Distribution and Excretion
After intravenous administration, tetrofosmin is rapidly cleared from the blood and taken up by the heart, skeletal muscle, liver, spleen and kidneys.
Refer to [DB09160]
This pharmacokinetic property has not been fully studied.
Refer to [DB09160]
Applications
UsesTetrofosmin is used in diagnostic imaging procedures. A dual tracer imager for patients with hyperparathyroidism. A radiotracers for SPECT imaging.
Suppliers4 total
Alfa Chemistry1-516-6625404 · [email protected]
Alfa Chemistry+1-5166625404 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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