Tilomisole

HCID 42747

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Basic information

CAS: 58433-11-7
Standard SMILES: O=C(O)Cc1sc2nc3ccccc3n2c1-c1ccc(Cl)cc1
InChIKey: PUYFLGQZLHVTHX-UHFFFAOYSA-N
Molecular formula: C17H11ClN2O2S
Average molar mass: 342.8 g/mol
Monoisotopic mass: 342.02297627

Overview

Tilomisole is a small molecule drug. Tilomisole has a monoisotopic molecular weight of 342.02 Da.

Names & identifiers

Preferred name: Tilomisole
IUPAC: 2-[1-(4-chlorophenyl)-[1,3]thiazolo[3,2-a]benzimidazol-2-yl]acetic acid
English name: Tilomisole
Molecular formula: C17H11ClN2O2S
Molecular weight: 342.8

Names & synonyms

TILOMISOLE58433-11-7TilomisolTilomisolumWy-18251WY-18,251651G60U3723-(p-Chlorophenyl)thiazolo(3,2-a)benzimidazole-2-acetic acidDTXSID40207137RefChem:933072DTXCID401296282-[1-(4-chlorophenyl)-[1,3]thiazolo[3,2-a]benzimidazol-2-yl]acetic acid

Show more names

Thiazolo[3,2-a]benzimidazole-2-acetic acid, 3-(4-chlorophenyl)-

Wy 18251Thiazolo(3,2-a)benzimidazole-2-acetic acid, 3-(4-chlorophenyl)Tilomisol [Spanish]Tilomisolum [Latin]Tilomisole [USAN:INN]UNII-651G60U372TILOMISOLE [INN]Tilomisole (USAN/INN)

Database identifiers

CAS: 58433-11-7
PubChem CID: 42747
DTXSID: DTXSID40207137
ChEMBL: CHEMBL2104737
UNII: 651G60U372
Nikkaji: J22.806K

Properties

Computed structural properties

XLogP: 4.3
Topological polar surface area: 82.8 Å²
Hydrogen bond donors: 1
Hydrogen bond acceptors: 4
Rotatable bonds: 3
Heavy atoms: 23
Formal charge: 0
Complexity: 458

Physicochemical properties

FDA UNII: 651 G60U372 · 651G60U372

Chemistry & industry

Applications · 1 item

UsesTilomisole (Wy 18251) is a benzimidazothiazole experimental agent with anti-inflammatory activity. Tilomisole causes less agranulocytosis than levamisole, but retains immunomodulating capabilities. Tilomisole is orally active. Tilomisole has the potential for the research of cancer and inflammation[1][2].