Basic information
- CAS
60200-06-8- Standard SMILES
Nc1cc(C(Cl)=C(Cl)Cl)c(S(N)(=O)=O)cc1S(N)(=O)=O- InChIKey
QOVTVIYTBRHADL-UHFFFAOYSA-N- Molecular formula
- C8H8Cl3N3O4S2
- Average molar mass
- 380.7 g/mol
- Monoisotopic mass
- 378.902181
Overview
4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide is a member of benzenes and a sulfonamide.
Names & identifiers
- Preferred name
- Clorsulon
- IUPAC
- 4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide
- English name
- Clorsulon
- Molecular formula
- C8H8Cl3N3O4S2
- Molecular weight
- 380.66
Names & synonyms
CLORSULON60200-06-8CuratremClorsuloneClorsulonum4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamideClorsuronMK-4011,3-Benzenedisulfonamide, 4-amino-6-(trichloroethenyl)-4-Amino-6-(trichloroethenyl)-1,3-benzenedisulfonamideDTXSID8045488EG1ZDO6LRD
Show more names
chlorsulonCLORSULON USPorsuLl631529keluosuolongClorsulon (MK-401Clorsulon (200 mg)
NSC-758901Curatrem Drench, Curatrem Drench For CattleDTXCID6025488L 631,529RefChem:57675262-100-24-amino-6-(1,2,2-trichlorovinyl)benzene-1,3-disulfonamideMFCD00072006
Database identifiers
- CAS
60200-06-8- PubChem CID
- 43231
- DTXSID
DTXSID8045488- ChEMBL
CHEMBL1474129- ChEBI
CHEBI:94811
Properties
Computed structural properties
- XLogP
- 1.2
- Topological polar surface area
- 163 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 7
- Rotatable bonds
- 3
- Heavy atoms
- 20
- Formal charge
- 0
- Complexity
- 604
Experimental & physicochemical properties
Human DrugsPharmaceuticals
Animal Drugs
FDA approved animal drugs -> Active ingredient
Pharmaceuticals -> UK Veterinary Medicines Directorate List
Collision Cross Section183.5 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physicochemical properties
- Melting point
- 194 · 194-203°C
- Boiling point
- 651.7 · 651.7±65.0 °C(Predicted)
- Density
- 1.8 · 1.800±0.06 g/cm3(Predicted)
- storage temp.
- 2 · Keep in dark place,Inert atmosphere,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 9.16 · 9.16±0.60(Predicted)
- color
- White
- Major Application
- forensics and toxicologypharmaceutical (small molecule)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 3.3% (1 of 30) of reports.
Warning
H319 (96.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
P260, P264+P265, P280, P305+P351+P338, P319, P337+P317, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 30 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory InformationClorsulon: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and CategoriesEye Irrit. 2 (96.7%)
Safety data
- PPE
- Eyeshields, Gloves, type N95 (US)
- wgk
- 2
- rtecs
- CZ9090000
- hs_code
- 29350090
- Toxicity
- LD50 in mice (mg/kg): 761 i.p.; >10,000 orally (Ostlind)
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- safety_code
- 24/25
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H319
- Precautionary statements
- P305+P351+P338
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Agents that kill parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.
Agents used to treat cestode, trematode, or other flatworm infestations in man or animals.
Uses & manufacturing
Use ClassificationPharmaceuticals
Applications
DescriptionClorsulon is a sulfonamide antiparasitic agent. It induces swelling and blebbing and reduces motility of F. hepatica mature flukes when used at a concentration of 10 μg/ml. In vivo, clorsulon (3.5-15 mg/kg) reduces the number of flukes in a goat model of F. hepatica infection. It completely eradicates naturally acquired F. hepatica adult flukes in sheep and cattle when administered at a dose of 7 mg/kg. Formulations containing clorsulon have been used in the treatment of liver flukes in sheep and cattle.
Usesanalgesic, antiinflammatory
UsesA benzenedisulfonamide derivative with fasciolicidal activity. Anthelmintic (Trematodes).
Upstream & downstream products
Upstream raw materials
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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