N-Bromoacetamide (HCID 4353)

Overview

N-bromoacetamide is a white powder. (NTP, 1992)

Names & identifiers

Preferred name: N-Bromoacetamide
IUPAC: N-bromoacetamide
English name: N-Bromoacetamide
Molecular formula: C2H4BrNO
Molecular weight: 137.96

Names & synonyms

n-bromoacetamide79-15-2Acetamide, N-bromo-Acetobromamide0AQ6MWH7ZBDTXSID5024633RefChem:163002DTXCID704633201-181-0MFCD00037097Acetobromamide; NBACCRIS 4590

Show more names

N-Bromacetamidn-bromo-acetamidNBAAcetobromamideN-Bromoacetamide-95%N-Bromoacetamide >N-BROMOACETAMIDE (NBA)

EINECS 201-181-0UNII-0AQ6MWH7ZBN-bromo-acetamideN-Bromoacetamide, powderLopac-B-2377SCHEMBL1658Lopac0_000191N-BROMOACETAMIDE [MI]

Database identifiers

CAS: 79-15-2
PubChem CID: 4353
DTXSID: DTXSID5024633
ChEMBL: CHEMBL1256514
UNII: 0AQ6MWH7ZB
EC Number: 201-181-0
Nikkaji: J4.228E

Properties

Computed structural properties

XLogP: 0.1
Topological polar surface area: 29.1 Å²
Hydrogen bond donors: 1
Hydrogen bond acceptors: 1
Rotatable bonds: 0
Heavy atoms: 5
Formal charge: 0
Complexity: 44.9

Experimental & physicochemical properties

SpringerMaterials PropertiesCrystal structure

Solubilitygreater than or equal to 100 mg/mL at 72 °F (NTP, 1992)

Melting Point226 °F (NTP, 1992)

Physical DescriptionN-bromoacetamide is a white powder. (NTP, 1992)

Physicochemical properties

Melting point: 102 · 102-105°C
Boiling point: 127 · 127-130 °C(Press: 16 Torr)
Density: 1.7 · 1.7000 (rough estimate)
refractive index: 1.474 · 1.4740 (estimate)
storage temp.: -20 °C · -20°C
solubility: very slightly in Chloroform
form: powder
pka: 9.41 · 9.41±0.46(Predicted)
color: white to yellow
biological source: synthetic (organic)
Water Solubility: Soluble in water.
Merck: 14 · 14,1398
BRN: 969346 · 969346
InChI: 1S/C2H4BrNO/c1-2(5)4-3/h1H3,(H,4,5)
InChIKey: VBTQNRFWXBXZQR-UHFFFAOYSA-N
SMILES: CC(=O)NBr
CAS DataBase Reference: 79 · 79-15-2(CAS DataBase Reference)
FDA UNII: 0 AQ6MWH7ZB · 0AQ6MWH7ZB
EPA Substance Registry System: N-Bromoacetamide (79-15-2)
UNSPSC Code: 12352202 · 12352202
NACRES: 77 · NA.77
Symbol(GHS): 5 · GHS05,GHS07
Signal word: Danger
Hazard statements: 302 · H302+H312+H332-H314-H319-H335
Precautionary statements: 260 · P260-P264-P270-P271-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P405-P501-P303+P361+P353-P305+P351+P338-P310
PPE: 95 · dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes: Xi
Risk Statements: 36 · 36/37/38
Safety Statements: 26 · 26-36
RIDADR: 3261 · 3261
WGK Germany: 3 · 3
F: 8 · 8
TSCA: TSCA listed
HazardClass: 8 · 8
PackingGroup: III
HS Code: 29299090 · 29299090
Storage Class: 11 · 11 - Combustible Solids

Safety & regulation

GHS classification

GHS Classification · 4 items

Danger

H314 (11.1%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

P260, P261, P264, P264+P265, P271, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P319, P321, P332+P317, P337+P317, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 45 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory InformationChemical: Acetamide, N-bromo-

DOT LabelCorrosive

Fire HazardsFlash point data are not available for this chemical, but it is probably combustible. (NTP, 1992)

Health HazardsSYMPTOMS: This compound may cause irritation of tissues on contact. Related compounds such as bromoacetate are highly toxic and may cause fatal cardiac arrhythmias and delayed seizures.

Reactive GroupAmides and Imides

Reactivity ProfileN-BROMOACETAMIDE is sensitive to light, moisture, and heat. (NTP, 1992). It decomposes rapidly at elevated temperatures, in the presence of moisture and light.

Safety & protection

Fire FightingFires involving this compound should be controlled using a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

First Aid · 1 item

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1 item

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a strong soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Isolation and EvacuationExcerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

Personal Protective Equipment (PPE) · 1 item

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Safety data

F: 8
PPE: dust mask type N95 (US), Eyeshields, Gloves
wgk: 3
tsca: TSCA listed
ridadr: 3261
hs_code: 29299090
risk_code: 36/37/38
Signal word: Danger
Symbol(GHS): GHS05,GHS07
hazard_code: Xi
safety_code: 26-36
hazard_class: 8
Storage Class: 11 - Combustible Solids
packing_group: III
Hazard statements: H302+H312+H332-H314-H319-H335
Precautionary statements: P260-P264-P270-P271-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P405-P501-P303+P361+P353-P305+P351+P338-P310

Chemistry & industry

Pharmacology

MeSH Pharmacological ClassificationAgents destructive to snails and other mollusks.

Uses & manufacturing

General Manufacturing InformationAcetamide, N-bromo-: ACTIVE

Applications · 3 items

UsesAbolishes the rapid inactivation of membrane sodium- and potassium-ion channels.

UsesN-bromoacetamide annihilates the rapid inactivation of membrane sodium-ion channels. Also functions in the kinetics of cardiac sodium ion channels.

General DescriptionWhite powder.