Basic information
- CAS
61270-78-8- Standard SMILES
O=C([O-])C1=C(CSc2nnnn2CS(=O)(=O)[O-])CS[C@@H]2[C@H](NC(=O)[C@H](O)c3ccccc3)C(=O)N12.[Na+].[Na+]- InChIKey
NAXFZVGOZUWLEP-RFXDPDBWSA-L- Molecular formula
- C18H16N6Na2O8S3
- Average molar mass
- 586.5 g/mol
- Monoisotopic mass
- 585.99871357
Overview
Cefonicid sodium is an organic sodium salt. It contains a cefonicid(2-).
Names & identifiers
- Preferred name
- Cefonicid Sodium
- IUPAC
- disodium;(6R,7R)-7-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-8-oxo-3-[[1-(sulfonatomethyl)tetrazol-5-yl]sulfanylmethyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
- English name
- Cefonicid sodium
- Molecular formula
- C18H19N6NaO8S3
- Molecular weight
- 566.55
Names & synonyms
CEFONICID SODIUM61270-78-8Cefonicid disodium saltMonocidCefonicide sodiumDTXSID0046642F74MFL78A1SK&F D-75073-Z(SUB 2)SK&F-D-75073-Z(SUB 2)CHEBI:3492DTXCID8026642RefChem:57270
Show more names
SKF D-75073-Z2Monocid sodiumCefonicid sodiumrCefonicid Sodium (1 g)Cefonicid (sodium salt)CefonicidSodium(Sterile)Cefonicid sodium USP/EP/BP
190181-58-9cefonicid disodiumSK&F D-75073-Z2SKF 75073Monocid (TN)Cefonicid (sodium)MSK12033Nadisodium;(6R,7R)-7-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-8-oxo-3-[[1-(sulfonatomethyl)tetrazol-5-yl]sulfanylmethyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Database identifiers
- CAS
61270-78-8- PubChem CID
- 43593
- DTXSID
DTXSID0046642- ChEMBL
CHEMBL1201005
Properties
Computed structural properties
- Topological polar surface area
- 270 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 13
- Rotatable bonds
- 7
- Heavy atoms
- 37
- Formal charge
- 0
- Complexity
- 980
Experimental & physicochemical properties
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Collision Cross Section205.7 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physicochemical properties
- Melting point
- 160 °C · > 160°C
- storage temp.
- 2 · Inert atmosphere,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Pale Yellow
- InChIKey
- BNXOGMOZTWSPSS-VDEWIJQXNA-N
- SMILES
- C(C1=C(CS[C@]2([H])[C@H](NC(=O)[C@@H](C3C=CC=CC=3)O)C(=O)N12)CSC1=NN=NN1CS(O)(=O)=O)(=O)O.[NaH] |&1:5,7,11,r|
- CAS DataBase Reference
- 61270 · 61270-78-8(CAS DataBase Reference)
- FDA UNII
- 74 MFL78A1 · F74MFL78A1
- Symbol(GHS)
- 8 · GHS08
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Danger
H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]
P233, P260, P261, P271, P272, P280, P284, P302+P352, P304+P340, P321, P333+P317, P342+P316, P362+P364, P403, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 2 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Hazard Classes and CategoriesSkin Sens. 1 (100%)
Safety data
- hs_code
- 2941906000
- Signal word
- Danger
- Symbol(GHS)
- GHS08
- Hazard statements
- H317-H334
- Precautionary statements
- P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P261-P285-P304+P341-P342+P311-P501
Chemistry & industry
Pharmacology
MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.
Applications
DescriptionCefonicid sodium is the first of the second-generation cephalosporin antibiotics with a long enough serum half-life b4.5 hr.) to allow once-daily i.v. administration. Cefonicid is resistant to β-lactamases produced by S. aureus, H. influenzae, -N. gonorrhea, and related organisms. As with other drugs of this class, it is useful in the treatment of urinary tract and lower respiratory tract infections, skin and skin structure infections, and bone and joint infections, as well as in surgical prophylaxis.
DescriptionCefonicid is a second-generation cephalosporin antibiotic. Like other cephalosporins, cefonicid interferes with cell wall biosynthesis in bacteria, leading to lysis of the infectious organism. It is a broad-spectrum antibiotic and has a prolonged serum elimination half-life in animals.
UsesA semi-synthetic cephalosporin antibiotic related to Cefamandole. Antibacterial.
Suppliers100 total
Hebei Jingbo New Material Technology Co., Ltd+86-19931165850 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
HebeiShuoshengImportandExportco.,Ltd+86-18532138899 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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