N-tert-Butyl-a-phenylnitrone

UsesN-tert-Butyl-a-phenylnitrone is a commonly-used free radical trap. It contains radical scavenging activity and an ability to inhibit Cox-2 (cyclooxygenase-2). N-tert-Butyl-a-phenylnitrone is an antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. N-tert-Butyl-a-phenylnitrone inhibits lipid peroxidation in rat liver microsomes. It also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.

UsesN-tert-Butyl-α-phenylnitrone has been used:as a component of Dneasy Blood&Tissue buffer to preserve the oxidized state of DNA extracted from human non-tumorigenic epithelial breast (MCF10A) cellsas a free radical scavenger of reactive oxygen species (ROS) in microglial (MG) cell linesto attenuate fibroblast senescence in unstable oral squamous cell carcinomas (GU-OSCC)

UsesSpin trap reagent for carbon- or oxygen- or nitrogen-centered free radicals.

General DescriptionMost commonly-used free radical trap. An antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. Inhibits lipid peroxidation in rat liver microsomes. Also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.