Elastins
Basic information
- CAS
9007-58-3- Standard SMILES
CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)NCC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)NC)C(C)C- InChIKey
DPUYCSDGMSDKKV-MKBYFEBXSA-N- Molecular formula
- C27H48N6O6
- Average molar mass
- 552.7 g/mol
- Monoisotopic mass
- 552.36353327
Overview
N-Acetyl-L-leucyl-L-isoleucylglycyl-L-valyl-N-methyl-L-prolinamide is an oligopeptide.
Names & identifiers
- Preferred name
- Elastins
- IUPAC
- (2S)-1-[(2S)-2-[[2-[[(2S,3S)-2-[[(2S)-2-acetamido-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-3-methylbutanoyl]-N-methylpyrrolidine-2-carboxamide
- English name
- ELASTIN
- Molecular formula
- C27H48N6O6
- Molecular weight
- 552.70662
Names & synonyms
ELASTINElastins9007-58-3VRC4754D50(2S)-1-[(2S)-2-[[2-[[(2S,3S)-2-[[(2S)-2-acetamido-4-methyl-pentanoyl]amino]-3-methyl-pentanoyl]amino]acetyl]amino]-3-methyl-butanoyl]-N-methyl-pyrrolidine-2-carboxamide(2S)-1-((2S)-2-((2-(((2S,3S)-2-(((2S)-2-acetamido-4-methyl-pentanoyl)amino)-3-methyl-pentanoyl)amino)acetyl)amino)-3-methyl-butanoyl)-N-methyl-pyrrolidine-2-carboxamideRefChem:136452232-701-4Elastin from pigUNII-VRC4754D50EINECS 232-701-4(2S)-1-[(2S)-2-[[2-[[(2S,3S)-2-[[(2S)-2-acetamido-4-methylpentanoyl]amino]-3-methylpentanoyl]amino]acetyl]amino]-3-methylbutanoyl]-N-methylpyrrolidine-2-carboxamide
Show more names
Elastin-Like PolypeptidesElastineelastinaseBETA-ELASTINElastin, pigELASTIN, BOVINEElastin(Bonito)
NSC 657641AC1L96WZC00373SCHEMBL28920635CHEBI:177837DPUYCSDGMSDKKV-MKBYFEBXSA-NDTXSID801009134NS00013654
Properties
Computed structural properties
- XLogP
- 0.1
- Topological polar surface area
- 166 Ų
- Hydrogen bond donors
- 5
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 14
- Heavy atoms
- 39
- Formal charge
- 0
- Complexity
- 892
Experimental & physicochemical properties
Chemical ClassesBiological Agents -> Proteins
Cosmetics
Cosmetic ingredients (Elastin) -> CIR (Cosmetic Ingredient Review)
Skin conditioning; Smoothing
Physical DescriptionPowder; [Sigma-Aldrich MSDS]
Physicochemical properties
- storage temp.
- 2 · 2-8°C
- solubility
- 2 O: · H2O: soluble
- form
- powder
- color
- Off-white to light yellow
- biological source
- rat
- Water Solubility
- 2 O: · H2O: >10mg/mL (more soluble at pH>7)
- Cosmetics Ingredients Functions
- SKIN CONDITIONINGSMOOTHING
- Cosmetic Ingredient Review (CIR)
- ELASTIN (9007-58-3)
- InChIKey
- DPUYCSDGMSDKKV-XPEWSIIXNA-N
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Hazard information
Regulatory Information
Chemical: Elastins
Elastin: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Elastins: Environment tier I assessment
Hazards SummaryMay cause irritation; [Sigma-Aldrich MSDS]
Toxicology
Toxicity SummarySafe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org
Safety data
- F
- 10-21
- PPE
- Eyeshields, Gloves, type N95 (US)
- wgk
- 3
- hazard_code
- B
- safety_code
- 22-24/25
- Storage Class
- 13 - Non Combustible Solids
Chemistry & industry
Uses & manufacturing
Uses
CIR ingredient: Elastin
An insoluble protein extracted from mammalian organisms. [ChemIDplus]
Household ProductsInformation on 5 consumer products that contain Elastin in the following categories is provided:
Use ClassificationCosmetics -> Skin conditioning; Smoothing
Applications
Useselastin (hydrolyzed) is a modified form of elastin that has better solubility, and thus is more convenient for use in cosmetic formulations than regular elastin.
Useselastin is a surface protective agent used in cosmetics to alleviate the effects of dry skin, enhance skin flexibility, improve skin feel, increase and improve the tension of the skin, and influence the formation of tropocollagen fibers when used in combination with soluble collagen. Preparations containing elastin and peptides derived from it are reported to promote wound healing. Reportedly, in such systems, elastin can absorb lipids from the skin, and when applied to scars, increase the structural glycoproteins and elastin available in the scar tissue. elastin is an elastic structural protein found in the dermis together with collagen, and is difficult to obtain in pure form. Collagen and elastin are similar, although elastin has a different amino acid composition and is found in lower concentrations. Its molecular size is also much smaller than collagen’s, and as a result, there is a tendency to believe that it penetrates the surface epidermal layers, thereby improving overall skin appearance, softness, and suppleness. elastin is often used in moisturizing products and those products for aging or mature skin.
UsesElastin mouse lung has been used as an extracellular matrix (ECM) protein for coating of plates.
General DescriptionElastin is an insoluble extracellular matrix protein and the core protein of elastic fibers that impart elasticity to skin. Histologically, an accumulation of disintegrated amorphous elastic fibers is observed in the solar elastosis region. Elastin is secreted as tropoelastin in the extracellular matrix. The biologic process of elastic fibers is complicated. It has multiple components and is assembled via several steps and stringently regulated developmental processes.
Related reactions
0 records
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Compound notes
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