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Basic information
- CAS
1219707-39-7- Standard SMILES
CN1CCN(c2ccc(N3C[C@H](CO)OC3=O)cc2F)C=N1- InChIKey
QLUWQAFDTNAYPN-LLVKDONJSA-N- Molecular formula
- C14H17FN4O3
- Average molar mass
- 308.31 g/mol
Names & identifiers
- Preferred name
- Delpazolid
- English name
- Delpazolid
- Molecular formula
- C14H17FN4O3
- Molecular weight
- 308.31
Names & synonyms
CS-2617DelpazolidLCB01-0371Delpazolid (LCB01-0371)Delpazolid, 10 mM in DMSOAntibiotic,Delpazolid,inhibit,Bacterial,InhibitorDELPAZOLIDLCB01-0371LCB 01-0371LCB-01-0371LCB010371LCB 010371
Show more names
LCB-010371(R)-3-(3-fluoro-4-(1-methyl-5,6-dihydro-1,2,4-triazin-4(1H)-yl)phenyl)-5-(hydroxymethyl)oxazolidin-2-one(5R)-3-[4-(5,6-Dihydro-1-methyl-1,2,4-triazin-4(1H)-yl)-3-fluorophenyl]-5-(hydroxymethyl)-2-oxazolidinone2-Oxazolidinone, 3-[4-(5,6-dihydro-1-methyl-1,2,4-triazin-4(1H)-yl)-3-fluorophenyl]-5-(hydroxymethyl)-, (5R)-
Database identifiers
- CAS
1219707-39-7- PubChem CID
- 44205191
- ChEMBL
CHEMBL1673408- UNII
- 43EP6XV33E
Properties
Physicochemical properties
- Boiling point
- 481.8 · 481.8±55.0 °C(Predicted)
- Density
- 1.44 · 1.44±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · Store at -20°C
- solubility
- 30 · DMSO:30.0(Max Conc. mg/mL);97.3(Max Conc. mM)
- form
- A crystalline solid
- pka
- 14.05 · 14.05±0.10(Predicted)
- color
- White to off-white
- FDA UNII
- 43 EP6XV33E · 43EP6XV33E
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319-H335
- Precautionary statements
- 261 · P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
Safety & regulation
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
Chemistry & industry
Applications
DescriptionDelpazolid is an oxazolidinone antibiotic. It is active against a wide range of Gram-positive bacterial clinical isolates, including resistant strains of several species, such as methicillin-resistant S. aureus (MRSA), methicillin-resistant coagulase-negative staphylococci (MRCNS), and penicillin-resistant S. pneumoniae (MICs = 0.125-4 μg/ml). Delpazolid increases survival in mouse models of systemic MRSA, E. faecalis, S. pneumoniae, and H. influenzae infection (ED50s = 2.96, 4.53, 2.28, and 9.96 mg/kg, respectively).
UsesDelpazolid is a novel oxazolidinone antibiotic agent which can inhibit the growth of MSSA and MRSA with a MIC90 of 2 μg/mL for both of them.
Upstream & downstream products
Upstream raw materials
Related reactions
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Compound notes
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