Basic information
- CAS
35115-60-7- Standard SMILES
CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)O- InChIKey
UUUHXMGGBIUAPW-CSCXCSGISA-N- Molecular formula
- C53H76N14O12
- Average molar mass
- 1,101.3 g/mol
- Monoisotopic mass
- 1,100.57671391
Overview
Teprotide is a peptide.
Names & identifiers
- Preferred name
- Teprotide
- IUPAC
- (2S)-1-[(2S)-1-[(2S,3S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-1-[(2S)-3-(1H-indol-3-yl)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid
- English name
- BPP 9A
- Molecular formula
- C53H76N14O12
- Molecular weight
- 1101.26
Names & synonyms
TEPROTIDE35115-60-7TepromideTeprotidumSQ-20881teprotidaSQ 20881C3E5QBF1R6DTXSID301029698SO-20881Bradykinin potentiator B, 2-L-tryptophan-3-de-L-leucine-4-de-L-proline-8-L-glutamine-BPP-9a
Show more names
DK84DBPP 9APYR-WPRPQIPPBPP 9A USP/EP/BPTeprotide, SQ20881BPP 9a Teprotide, SQ20881Bradykinin potentiator BPP9aBRADYKININ POTENTIATING FACTOR
Bradykinin Potentiating Peptide 9aBradykinin-Potentiating Peptide 9a(2S)-1-((2S)-1-((2S,3S)-2-(((2S)-5-amino-2-(((2S)-1-((2S)-5-guanidino-2-(((2S)-1-((2S)-3-(1H-indol-3-yl)-2-(((2S)-5-oxopyrrolidine-2-carbonyl)amino)propanoyl)pyrrolidine-2-carbonyl)amino)pentanoyl)pyrrolidine-2-carbonyl)amino)-5-oxo-pentanoyl)amino)-3-methyl-pentanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylic acid(2S)-1-[(2S)-1-[(2S,3S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S)-5-guanidino-2-[[(2S)-1-[(2S)-3-(1H-indol-3-yl)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxo-pentanoyl]amino]-3-methyl-pentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acidPeptide 9a, Bradykinin-PotentiatingNonapeptide Converting Enzyme InhibitorNonapeptide-Converting Enzyme InhibitorEnzyme Inhibitor, Nonapeptide-Converting
Properties
Computed structural properties
- XLogP
- -0.9
- Topological polar surface area
- 387 Ų
- Hydrogen bond donors
- 10
- Hydrogen bond acceptors
- 13
- Rotatable bonds
- 24
- Heavy atoms
- 79
- Formal charge
- 0
- Complexity
- 2,330
Physicochemical properties
- Density
- 1.54 · 1.54±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · -20°C
- solubility
- 1 mg/mL, · water: soluble 1 mg/mL, clear, colorless
- pka
- 3.44 · 3.44±0.20(Predicted)
- form
- Powder
- biological source
- synthetic (organic)
- Water Solubility
- 1 mg/mL, · water: soluble 1mg/mL, clear, colorless
- Sequence
- {Glp}-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro
- InChIKey
- UUUHXMGGBIUAPW-CSCXCSGISA-N
- NCI Dictionary of Cancer Terms
- angiotensin-converting enzyme inhibitor
- FDA UNII
- 3 E5QBF1R6 · C3E5QBF1R6
- UNSPSC Code
- 12352200 · 12352200
- NACRES
- 77 · NA.77
- PPE
- 95 · Eyeshields, Gloves, type N95 (US)
- WGK Germany
- 3 · 3
- Storage Class
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- PPE
- Eyeshields, Gloves, type N95 (US)
- wgk
- 3
- Storage Class
- 11 - Combustible Solids
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Applications
UsesTeprotide is an inhibitor of angiotensin-converting enzyme (ACE) inhibitor. Teprotide can be used to study hypertensive[1].
Suppliers83 total
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
江苏艾康生物医药研发有限公司025-58851090 19370895928 · [email protected]
上海哲研生物科技有限公司021-18017610038 18017610038 · [email protected]
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
Hangzhou Go Top Peptide Biotech0571-88211921 · [email protected]
南京昱盛康生物科技有限公司
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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