Completing data — usually done within a minute
Basic information
- CAS
101827-46-7- Standard SMILES
CN(Cc1ccc(C(C)(C)C)cc1)Cc1cccc2ccccc12.Cl- InChIKey
LJBSAUIFGPSHCN-UHFFFAOYSA-N- Molecular formula
- C23H28ClN
- Average molar mass
- 353.9 g/mol
- Monoisotopic mass
- 353.19102758
Overview
Butenafine hydrochloride is the hydrochloride salt of butenafine. An inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes, it is used for treatment of dermatological fungal infections. It has a role as an EC 1.14.13.132 (squalene monooxygenase) inhibitor and an antifungal drug. It is a hydrochloride and an ammonium salt. It contains a butenafine.
Names & identifiers
- Preferred name
- Butenafine Hydrochloride
- IUPAC
- 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine;hydrochloride
Names & synonyms
Butenafine hydrochloride101827-46-7Butenafine HCLMentaxVolleyKP-363Mentax-TCN-(p-tert-Butylbenzyl)-N-methyl-1-naphthalenemethylamine hydrochlorideDTXSID2048589Lotrimin UltraJock Itch CreamAthletes Foot Ultra
Show more names
R8XA2029ZICHEBI:31325Lotrimin Ultra RingwormN-4-tert-Butylbenzyl-N-methyl-1-naphthalenemethylamine hydrochlorideDTXCID20285151-Naphthalenemethanamine, N-((4-(1,1-dimethylethyl)phenyl)methyl)-N-methyl-, hydrochlorideN-((4-(1,1-Dimethylethyl)phenyl)methyl)-N-methyl-1-naphthalenemethanamine hydrochlorideN-[[4-(1,1-Dimethylethyl)phenyl]methyl]-N-methyl-1-naphthalenemethanamine hydrochloride
Database identifiers
- CAS
101827-46-7- PubChem CID
- 443867
- DTXSID
DTXSID2048589- ChEMBL
CHEMBL1200397- ChEBI
CHEBI:31325- UNII
- R8XA2029ZI
- EC Number
- 642-354-4
Properties
Computed structural propertiesFilling in
- Topological polar surface area
- 3.2 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 1
- Rotatable bonds
- 5
- Heavy atoms
- 25
- Formal charge
- 0
- Complexity
- 374
Experimental & physicochemical properties
Human Drugs
Breast Feeding; Lactation; Milk, Human; Anti-Infective Agents; Antifungal Agents
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Safety & regulation
GHS classification
GHS Classification
Warning
H312 (97.6%): Harmful in contact with skin [Warning Acute toxicity, dermal]
P280, P302+P352, P317, P321, P362+P364, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 42 reports by companies from 2 notifications to the ECHA C&L Inventory.
Hazard information
Hazard Classes and CategoriesAcute Tox. 4 (97.6%)
Toxicology
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
Chemistry & industry
Pharmacology
FDA Pharmacological Classification
BUTENAFINE HYDROCHLORIDE
Benzylamines [CS]; Benzylamine Antifungal [EPC]
MeSH Pharmacological ClassificationSubstances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
Related reactions
5 records
Compound notes
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