4-(3-Endo-hydroxy-8-azabicyclo[3.2.1]oct-8-yl)naphthalene-1-carbonitrile
Basic information
- CAS
870888-46-3- Standard SMILES
N#Cc1ccc(N2[C@@H]3CC[C@H]2CC(O)C3)c2ccccc12- InChIKey
ATKWLNSCJYLXPF-FICVDOATNA-N- Molecular formula
- C18H18N2O
- Average molar mass
- 278.3 g/mol
- Monoisotopic mass
- 278.1419132
Overview
A selective androgen receptor modulator.
Names & identifiers
- Preferred name
- 4-(3-Endo-hydroxy-8-azabicyclo[3.2.1]oct-8-yl)naphthalene-1-carbonitrile
- IUPAC
- 4-[(1R,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]naphthalene-1-carbonitrile
- English name
- AC-262536
- Molecular formula
- C18H18N2O
- Molecular weight
- 278.35
Names & synonyms
AC-262536870888-46-3U8VS41J5O6AC 2625364-(3-endo-Hydroxy-8-azabicyclo(3.2.1)oct-8-yl)naphthalene-1-carbonitrile4-(3-endo-hydroxy-8-azabicyclo[3.2.1]oct-8-yl)naphthalene-1-carbonitrile4-[(1R,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]naphthalene-1-carbonitrile4-(3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl)naphthalene-1-carbonitrile1-Naphthalenecarbonitrile, 4-((3-endo)-3-hydroxy-8-azabicyclo(3.2.1)oct-8-yl)-UNII-U8VS41J5O6orb1305214SCHEMBL4879625
Show more names
AC262AC-262,356ACP-262AccadineAC262AC-262536 powderAC-262536, 10 mM in DMSO9-[1,1'-biphenyl]-4-yl-9H-Carbazol-3-amine4-(3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl)naphthalene-1-
SCHEMBL4881906CHEMBL3084525SCHEMBL31453006DTXSID701336168GLXC-22637EX-A4672EX-A7097MSK14545
Properties
Computed structural properties
- XLogP
- 3.5
- Topological polar surface area
- 47.3 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 1
- Heavy atoms
- 21
- Formal charge
- 0
- Complexity
- 428
Experimental & physicochemical properties
DrugsPharmaceuticals -> Listed in ZINC15
Physicochemical properties
- Melting point
- 158 · 158-162°C
- Boiling point
- 526 · 526.0±45.0 °C(Predicted)
- Density
- 1.28 · 1.28±0.1 g/cm3(Predicted)
- storage temp.
- 2 · 2-8°C
- solubility
- DMSO: Soluble
- pka
- 14.73 · 14.73±0.20(Predicted)
- form
- Solid
- color
- White to off-white
- Major Application
- forensics and toxicologypharmaceutical (small molecule)
- InChI
- InChI=1/C18H18N2O/c19-11-12-5-8-18(17-4-2-1-3-16(12)17)20-13-6-7-14(20)10-15(21)9-13/h1-5,8,13-15,21H,6-7,9-10H2/t13-,14+,15+
- InChIKey
- ATKWLNSCJYLXPF-FICVDOATNA-N
- SMILES
- O[C@H]1C[C@H]2CC[C@H](N2C2=CC=C(C#N)C3C=CC=CC2=3)C1 |&1:1,3,6,r|
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
- Storage Class
- 11 - Combustible Solids
Chemistry & industry
Applications
UsesAC-262536 is a hydrocarbon organic matter and can be used as pharmaceutical intermediates.
General DescriptionAC-262536 is a selective nonsteroidal androgen receptor modulator (SARM) with beneficial anabolic effects. AC-262536 has potent agonist activity against androgen receptors with affinity in the low nanomolar range (1-10 nM). It is another novel drug put forth by Acadia, just like ACP-105. It is a SARM by design, as it selectively binds to the androgen receptor, just like all the other SARMs. AC-262536 came into light in 2007 and even though 13 years have passed, little research has been done on this compound.
Upstream & downstream products
Upstream raw materials
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