Basic information
- CAS
121369-64-0- Standard SMILES
CN(C)C(=N)N=C(N)N.NCC(=O)O- InChIKey
KOFRCHIVYXPUNL-UHFFFAOYSA-N- Molecular formula
- C6H16N6O2
- Average molar mass
- 204.23 g/mol
- Monoisotopic mass
- 204.13347375
Names & identifiers
- Preferred name
- Metformin glycinate
- IUPAC
- 2-aminoacetic acid;3-(diaminomethylidene)-1,1-dimethylguanidine
- English name
- METFORMIN
- Molecular formula
- C4H11N5
- Molecular weight
- 129.16
Names & synonyms
METFORMIN GLYCINATEMetformin glycinate [INN]121369-64-0UNII-YEI21W005YYEI21W005Y2-aminoacetic acid;3-(diaminomethylidene)-1,1-dimethylguanidineN,N-Dimethyl-1,2,3-triimidodicarbonic diamide glycinate (1:1)DMMET-01DTXSID80659257KOFRCHIVYXPUNL-UHFFFAOYSA-NMETFORMIN GLYCINATE [WHO-DD]N,N-Dimethylimidodicarbonimidic diamide 2-aminoacetic acid
Show more names
Metformin (Synonyms:1,1-DIMETHYLBIGUANIDE
Glycine--N'-(diaminomethylidene)-N,N-dimethylguanidine (1/1)
Database identifiers
- CAS
121369-64-0- PubChem CID
- 44520175
- DTXSID
DTXSID80659257- ChEMBL
CHEMBL2108299- UNII
- YEI21W005Y
Properties
Computed structural properties
- Topological polar surface area
- 155 Ų
- Hydrogen bond donors
- 5
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 3
- Heavy atoms
- 14
- Formal charge
- 0
- Complexity
- 175
Physicochemical properties
- FDA UNII
- 21 W005Y · YEI21W005Y
Chemistry & industry
Applications
UsesMetformin (1,1-Dimethylbiguanide) glycinate inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin glycinate also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin glycinate regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo[1][2][3][4][5][6][7].
Suppliers2 total
上海陶术生物科技股份有限公司13564774135 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
Related reactions
1 records
Compound notes
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