Basic information
- CAS
57452-98-9- Standard SMILES
O=C(C1CCCCC1)N1CC(=O)N2CCc3ccccc3[C@@H]2C1- InChIKey
FSVJFNAIGNNGKK-KRWDZBQOSA-N- Molecular formula
- C19H24N2O2
- Average molar mass
- 312.4 g/mol
- Monoisotopic mass
- 312.18377801
Overview
(R)-Praziquantel is under investigation in clinical trial NCT02271984 (Relative Bioavailability Trial of L-Praziquantel in Healthy Volunteers).
Names & identifiers
- Preferred name
- Arpraziquantel
- IUPAC
- (11bR)-2-(cyclohexanecarbonyl)-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
- English name
- l-Praziquantel
- Molecular formula
- C19H24N2O2
- Molecular weight
- 312.41
Names & synonyms
(R)-Praziquantel57452-98-9(R)-(-)-Praziquantel(-)-PraziquantelL-praziquantelArpraziquantelPraziquantel, (R)-Praziquantel, (-)-L-PZQWF15T5925VMSC2499550AMSC-2499550A
Show more names
(R) PZQ(R)-PZQLopac-P-4668Lactic Acid Impurity 15(R)-2-(Cyclohexanecarbonyl)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one
DTXSID809047394H-Pyrazino(2,1-a)isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-, (11bR)-(11bR)-2-cyclohexanecarbonyl-1H,2H,3H,4H,6H,7H,11bH-piperazino(2,1-a)isoquinolin-4-one(11bR)-2-cyclohexanecarbonyl-1H,2H,3H,4H,6H,7H,11bH-piperazino[2,1-a]isoquinolin-4-oneRefChem:560034DTXCID101333847(-)-Pragiquantel(11bR)-2-(cyclohexanecarbonyl)-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one
Database identifiers
- CAS
57452-98-9- PubChem CID
- 445900
- DTXSID
DTXSID80904739- ChEMBL
CHEMBL1235551- UNII
Properties
Computed structural properties
- XLogP
- 2.7
- Topological polar surface area
- 40.6 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 1
- Heavy atoms
- 23
- Formal charge
- 0
- Complexity
- 472
Experimental & physicochemical properties
DrugsPharmaceuticals -> Listed in ZINC15
Human DrugsAntischistosomals and other antitrematode medicines
Physicochemical properties
- Melting point
- 113 · 113-115 °C
- Boiling point
- 544.1 · 544.1±50.0 °C(Predicted)
- Density
- 1.22 · 1.22±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · -20°C Freezer
- solubility
- Chloroform (Slightly), DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- -0.98 · -0.98±0.20(Predicted)
- color
- White to Pale Yellow
- FDA UNII
- 15 T5925V · WF15T5925V
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
H412 (100%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]
P273, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Hazard information
Hazard Classes and CategoriesAquatic Chronic 3 (100%)
Chemistry & industry
Pharmacology
ATC CodeP - Antiparasitic products, insecticides and repellents
MeSH Pharmacological ClassificationAgents that kill parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.
Applications
Uses(R)-Praziquantel is the active enantiomer of praziquantel regarding activity against juvenile S. mansoni infestations in mice. (R)-Praziquantel exhibits Schistosoma mansoni infestation inhibition in vitro and in vivo.
Suppliers32 total
Shaanxi LonierHerb Bio Technology Co Ltd+86-86-+86-86-029-87551862 15002946897 · [email protected]
杭州品高化工有限公司0571-87658025 · [email protected]
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
江苏艾康生物医药研发有限公司025-66061636 19370895928 · [email protected]
梯希爱（上海）化工贸易有限公司021-61109150 · [email protected]
United Life Science020-82099279 18988968278 · [email protected]
InvivoChem中国13549236410 · [email protected]
武汉永璨生物科技有限公司17702719238 · [email protected]
医恩医疗系统研发（上海）有限公司
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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