Basic information
- CAS
189302-40-7- Standard SMILES
NC(=NCC[C@H](N)C(=O)O)NO- InChIKey
KOBHCUDVWOTEKO-VKHMYHEASA-N- Molecular formula
- C5H12N4O3
- Average molar mass
- 176.17 g/mol
- Monoisotopic mass
- 176.09094026
Overview
Nomega-hydroxy-nor-l-arginine is a L-alpha-amino acid.
Names & identifiers
- Preferred name
- nor-NOHA
- IUPAC
- (2S)-2-amino-4-[[amino-(hydroxyamino)methylidene]amino]butanoic acid
- English name
- N-omega-Hydroxy-nor-L-arginine, diacetate salt
- Molecular formula
- C5H12N4O3
- Molecular weight
- 176.17
Names & synonyms
nor-NOHA189302-40-7N-Hydroxy-nor-L-arginineN-Hydroxy-nor-arginineNomega-hydroxy-nor-L-arginineJ842.499CU0F1149OFRN.OMEGA.-HYDROXY-NOR-L-ARGININE(2S)-2-Amino-4-(((hydroxyamino)iminomethyl)amino)butanoic acidButanoic acid, 2-amino-4-(((hydroxyamino)iminomethyl)amino)-, (S)-(2S)-2-amino-4-(N'-hydroxycarbamimidamido)butanoic acid(2S)-2-amino-4-[(E)-2-hydroxycarbamimidamido]butanoic acid
Show more names
nor-NOHA diacetateNOR-NOHA, 2CH3CO2HN-w-Hydroxy-L-norarginineN-o-Hydroxy-L-norarginineN---Hydroxy-nor-L-arginineN-w-Hydroxy-L-norarginine diacetate saltN-ω-Hydroxy-L-norarginine diacetate saltN-omega-Hydroxy-nor-L-arginine, diacetate salt(S,E)-2-aMino-4-(2-hydroxyguanidino)butanoic acid
(2S)-2-amino-4-((E)-2-hydroxycarbamimidamido)butanoic acidRefChem:854691N-omega-Hydroxy-L-norarginine291758-32-2NOR-N-OMEGA-HYDROXY-L-ARGININE(2S)-2-amino-4-[[amino-(hydroxyamino)methylidene]amino]butanoic acidCHEMBL1234777NNH
Properties
Computed structural properties
- XLogP
- -4.6
- Topological polar surface area
- 134 Ų
- Hydrogen bond donors
- 5
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 5
- Heavy atoms
- 12
- Formal charge
- 0
- Complexity
- 182
Experimental & physicochemical properties
DrugsPharmaceuticals -> Listed in ZINC15
Physicochemical properties
- Boiling point
- 391.515 · 391.515±52.00 °C(Press: 760.00 Torr)(predicted)
- Density
- 1.634 · 1.634±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
- storage temp.
- 0 °C · Store at 0°C
- solubility
- 50 mg/mL · water: 50 mg/mL
- form
- White to slightly yellowish powder.
- pka
- 2.209 · 2.209±0.10(predicted)
- color
- off-white
- Water Solubility
- 50 mg/mL · water: 50mg/mL
- InChIKey
- PQFYTZJPYBMTCT-QTNFYWBSSA-N
- SMILES
- N(O)\C(=N\CC[C@H](N)C(=O)O)\N.OC(=O)C.OC(=O)C
- FDA UNII
- 0 F1149OFR · U0F1149OFR
- UNSPSC Code
- 12352209 · 12352209
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- WGK 1
- Storage Class
- 11 - Combustible Solids
Chemistry & industry
Applications
UsesA potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC50 = 2 µM) and mouse macrophages (IC50 = 50 µM). Shown to specifically interact with the manganese-cluster of the enzyme active site. Does not function as a substrate or as an inhibitor for NOS. Hence, nor-NOHA may be a useful tool to study the interplays between arginase and NOS.
General DescriptionA potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC50 = 2 μM) and mouse macrophages (IC50 = 50 μM). Shown to specifically interact with the manganese-cluster of the enzyme active site. Does not function as a substrate or as an inhibitor for NOS. Hence, nor-NOHA may be a useful tool to study the interplays between arginase and NOS.
Suppliers36 total
陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
武汉敬康恩生物医药科技有限公司13720134139 086-15871494362 13720134139 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
Aladdin Scientific[email protected]
上海微佳禾生物科技有限公司17502176150; 17502176150 · [email protected]
毕佳索（上海毕得医药科技股份有限公司）400-6005915 · [email protected]
Nantong HI-FUTURE Biology Co., Ltd.+86-18051384581 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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