Basic information
- CAS
63758-79-2- Standard SMILES
c1ccc2c(CCC3CCNCC3)c[nH]c2c1- InChIKey
SADQVAVFGNTEOD-UHFFFAOYSA-N- Molecular formula
- C15H20N2
- Average molar mass
- 228.33 g/mol
- Monoisotopic mass
- 228.16264865
Overview
Indalpine is a member of indoles.
Names & identifiers
- Preferred name
- Indalpine
- IUPAC
- 3-(2-piperidin-4-ylethyl)-1H-indole
- English name
- Indalpine
- Molecular formula
- C15H20N2
- Molecular weight
- 228.33
Names & synonyms
INDALPINE63758-79-23-(2-(Piperidin-4-yl)ethyl)-1H-indoleIndalpinumindalpina4-[2-(3-indolyl)ethyl]piperidineV35562QSVTDTXSID802131961H-Indole, 3-(2-(4-piperidinyl)ethyl)-4-(2-(3-indolyl)ethyl)piperidine3-[2-(piperidin-4-yl)ethyl]-1H-indole(3-indolyl-2-ethyl)piperidine
Show more names
UpsteneLM-5008Indalpino3-(2-(4-piperidyl)ethyl)-indol3-(2-(4-piperidinyl)ethyl)-1h-indol3-[2-(4-Piperidinyl)ethyl]-1H-indole1H-Indole, 3-[2-(4-piperidinyl)ethyl]-
RefChem:148093DTXCID80135687264-445-43-(2-piperidin-4-ylethyl)-1H-indoleLM 5008Lipstene3-(2-(4-Piperidyl)ethyl)indoleCHEMBL276520
Database identifiers
- CAS
63758-79-2- PubChem CID
- 44668
- DTXSID
DTXSID80213196- ChEMBL
Properties
Computed structural properties
- XLogP
- 3.3
- Topological polar surface area
- 27.8 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 1
- Rotatable bonds
- 3
- Heavy atoms
- 17
- Formal charge
- 0
- Complexity
- 235
Experimental & physicochemical properties
DrugsPharmaceuticals -> Listed in ZINC15
Physicochemical properties
- FDA UNII
- 35562 QSVT · V35562QSVT
- RIDADR
- 3249 · 3249
- HazardClass
- 6.1 · 6.1(b)
- PackingGroup
- III
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- ridadr
- 3249
- hazard_class
- 6.1(b)
- packing_group
- III
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
Compounds that specifically inhibit the reuptake of serotonin in the brain.
Applications
DescriptionIndalpine is a non-tricyclic antidepressant with a serotonin selective profile. It is 6-7 times more potent than fluoxetine and clomipramine in inhibiting serotonin reuptake in vitro in rat brain synaptosomes. Statistically significant clinical effects within one week of onset of treatment have been reported. An anxiolytic effect may accompany the antidepressant effect. Indalpine appears devoid of anticholinergic and cardiovascular side effects and does not promote weight gain or affect appetite.
Suppliers11 total
安徽合诺生物科技有限公司0555-2761852
南京世洲生物科技有限公司025-025-85560043 17301488900 · [email protected]
安徽合诺生物科技有限公司18455579438
武汉丰泰威远科技有限公司+86-27-8746-5837 +86-18627785180 · [email protected]
武汉丰泰威远科技有限公司027-87465837 19945049750 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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