Basic information
- CAS
160790-21-6- Standard SMILES
CC[C@H](C)[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC)C(C)C)C(C)C)[C@@H](C)CC- InChIKey
XQIXDDUJIUUELO-JZOOTMHBSA-N- Molecular formula
- C42H77N9O11
- Average molar mass
- 884.1 g/mol
- Monoisotopic mass
- 883.57425431
Overview
GP2 peptide is under investigation in clinical trial NCT00524277 (Vaccine Therapy in Treating Patients With Breast Cancer).
Names & identifiers
- Preferred name
- GP-2 HER2-derived, hla-a2+ restricted peptide
- IUPAC
- (2S)-2-[[(2S,3S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]acetyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid
- English name
- GP2
- Molecular formula
- C42H77N9O11
- Molecular weight
- 884.11
Names & synonyms
HER2/neu (654-662) GP2160790-21-6GP-2 HER2-derived, hla-a2+ restricted peptideGP2 peptideUNII-FQA52PV28GFQA52PV28GGP-2(2S)-2-[[(2S,3S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]acetyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acidL-Isoleucyl-L-isoleucyl-L-seryl-L-alanyl-L-valyl-L-valylglycyl-L-isoleucyl-L-leucineL-Leucine, L-isoleucyl-L-isoleucyl-L-seryl-L-alanyl-L-valyl-L-valylglycyl-L-isoleucyl-orb321082orb1983945
Show more names
GP2IISAVVGILHER2/nue 654-662HER-2/NEU (654-662)ILE-ILE-SER-ALA-VAL-VAL-GLY-ILE-LEUH-ILE-ILE-SER-ALA-VAL-VAL-GLY-ILE-LEU-OH
SCHEMBL29481354HY-P1855TP1583NCGC00167173-01DA-74094MS-31637CS-0096586G12931
Properties
Computed structural properties
- XLogP
- 0.4
- Topological polar surface area
- 316 Ų
- Hydrogen bond donors
- 11
- Hydrogen bond acceptors
- 12
- Rotatable bonds
- 28
- Heavy atoms
- 62
- Formal charge
- 0
- Complexity
- 1,530
Physicochemical properties
- Boiling point
- 1209.5 · 1209.5±65.0 °C(Predicted)
- Density
- 1.147 · 1.147±0.06 g/cm3(Predicted)
- pka
- 3.41 · 3.41±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- Sequence
- Ile-Ile-Ser-Ala-Val-Val-Gly-Ile-Leu
- FDA UNII
- 52 PV28G · FQA52PV28G
Chemistry & industry
Applications
UsesHER2/neu (654-662) GP2 is a nine amino acid peptide derived from the human epidermal growth factor receptor 2 (HER2/nue, 654–662), induces HLA-A2-restricted cytotoxic T lymphocytes (CTL) reactive to various epithelial cancers[1][2].
Suppliers22 total
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
Aladdin Scientific[email protected]
中科华药(江苏)生物科技有限公司18020125070 · [email protected]
杭州思诺达医药科技有限责任公司0571-87213919 17306812703 · [email protected]
Creative Peptides[email protected]
太原百利恒康生物技术有限公司19135651983 · [email protected]
康明永瑞生物科技（苏州）有限公司17751201929; 17751201929 · [email protected]
杭州专肽生物技术有限公司17342063383 · [email protected]
凯试（上海）科技有限公司021-50135380 · [email protected]
杭州贝普泰生物医药有限公司0571-85350119 13305819357 · [email protected]
杭州固拓生物科技有限公司0571-88211921 17357109671 · [email protected]
成都云希化工有限公司+86-17380623303 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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