Hoechst 34580
Basic information
- CAS
23555-00-2- Standard SMILES
CN1CCN(c2ccc3nc(-c4ccc5nc(-c6ccc(N(C)C)cc6)[nH]c5c4)[nH]c3c2)CC1- InChIKey
VMCOQLKKSNQANE-UHFFFAOYSA-N- Molecular formula
- C27H29N7
- Average molar mass
- 451.6 g/mol
- Monoisotopic mass
- 451.24844395
Overview
structure in first source
Names & identifiers
- Preferred name
- Hoechst 34580
- IUPAC
- N,N-dimethyl-4-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]aniline
- English name
- HOECHST 34580
- Molecular formula
- C27H29N7
- Molecular weight
- 451.57
Names & synonyms
Hoechst 3458023555-00-2DTXSID40332276RefChem:923022DTXCID402833702'-(4-DIMETHYLAMINOPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLEN,N-dimethyl-4-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]anilineHoechst34580HOE 34580N,N-Dimethyl-4-(5-(4-methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazol]-2'-yl)anilineAKOS040744082DB04011
Show more names
ProaMineHoechst 34580 ，S0486Acid phosphatase, wheatHoechst 34580 (HOE 34580)2,50-bibenzimidazole, 20-[p-(dimethylamino)phenyl]-5-(4-methyl-1-piperazinyl)-Benzenamine, N,N-dimethyl-4-[5-(4-methyl-1-piperazinyl)[2,5'-bi-1H-benzimidazol]-2'-yl]-
HY-15560BBZBCP20754Hoechst-34580A924225orb1219368orb1706353SCHEMBL4997099
Database identifiers
- CAS
23555-00-2
Properties
Computed structural properties
- XLogP
- 4.4
- Topological polar surface area
- 67.1 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 4
- Heavy atoms
- 34
- Formal charge
- 0
- Complexity
- 672
Experimental & physicochemical properties
DrugsPharmaceuticals -> Listed in ZINC15
Physicochemical properties
- Melting point
- 300 ℃ · >300℃
- Boiling point
- 733.2 · 733.2±70.0 °C(Predicted)
- Density
- 1.28 · 1.280±0.06 g/cm3(Predicted)
- storage temp.
- 2 · 2-8°C(protect from light)
- solubility
- Soluble in dimethyl sulfoxide, water
- form
- powder
- pka
- 10.97 · 10.97±0.10, most acidic, temperature: 25 °C; 7.66 ± 0.42, most basic(at 25℃)
- color
- Yellow to green
- Appearance
- Yellow Solid
- λmax
- 392 nm · 392nm
- Biological Applications
- Detecting malaria infected red blood cells,polynucleotides; nucleic acid amplification; nucleic acid sequencing
- Symbol(GHS)
- 7 · GHS07
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302
- Precautionary statements
- P264-P270-P301+P312-P330-P501
Chemistry & industry
Applications
DescriptionHoechst 34580 is one of Hoechst stains which are Bis-benzimides used as blue fluorescent dyes to stain DNA.
UsesHoechst 34580 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution[1].
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