VK-28

HCID 4490594
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Basic information

CAS
312611-92-0
Standard SMILES
OCCN1CCN(Cc2ccc(O)c3ncccc23)CC1
InChIKey
XIXFNVDWEWCEOI-UHFFFAOYSA-N
Molecular formula
C16H21N3O2
Average molar mass
287.36 g/mol
Monoisotopic mass
287.16337691

Names & identifiers

Preferred name
VK-28
IUPAC
5-[[4-(2-hydroxyethyl)piperazin-1-yl]methyl]quinolin-8-ol
English name
VK-28
Molecular formula
C16H21N3O2
Molecular weight
287.36

Names & synonyms

VK-28312611-92-0DTXSID80403691RefChem:388366DTXCID50354545635-749-85-[[4-(2-hydroxyethyl)piperazin-1-yl]methyl]quinolin-8-ol5-((4-(2-Hydroxyethyl)piperazin-1-yl)methyl)quinolin-8-ol5-{[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]METHYL}QUINOLIN-8-OLMFCD06254693SCHEMBL113820orb1297775
Show more names
VK28,VK 28VK-28, 10 mM in DMSO8-Quinolinol, 5-[[4-(2-hydroxyethyl)-1-piperazinyl]methyl]-
SCHEMBL29381869XIXFNVDWEWCEOI-UHFFFAOYSA-NGLXC-03450EX-A4878VK-28?AKOS002664232HY-W686216SB17078

Database identifiers

CAS
312611-92-0
PubChem CID
4490594
DTXSID
DTXSID80403691
EC Number
635-749-8
Nikkaji
J2.057.922F

Properties

Computed structural properties

XLogP
1
Topological polar surface area
59.8 Ų
Hydrogen bond donors
2
Hydrogen bond acceptors
5
Rotatable bonds
4
Heavy atoms
21

Experimental & physicochemical properties

LogP0.54

Physicochemical properties

Melting point
230 ℃ · >230℃
storage temp.
2 · 2-8°C
solubility
2 O: · H2O: insoluble
form
solid
color
off-white
Symbol(GHS)
5 · GHS05

Safety & regulation

GHS classification

GHS Classification · 4 items

Danger

H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

P264+P265, P280, P305+P354+P338, and P317 (click each P-code to see the statement)

Aggregated GHS information provided per 39 reports by companies from 1 notifications to the ECHA C&L Inventory.

Hazard information

Hazard Classes and CategoriesEye Dam. 1 (100%)

Safety data

wgk
3
risk_code
41
Signal word
Danger
Symbol(GHS)
GHS05
hazard_code
Xi
safety_code
26-39

Chemistry & industry

Applications · 1 item

UsesVK-28, a brain-permeable iron chelator, inhibits both basal and Fe/ascorbate-induced mitochondrial membrane lipid peroxidation, with an IC50 of 12.7 μM. VK-28 exhibits significant neuroprotective effects on ICV-6-OHDA. VK-28 can be used for the research of Parkinson’s disease and other neurodegenerative diseases[1].

Suppliers29 total

沈阳中申泽康生物医学技术研究有限公司024-88590548 18698872706 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
武汉敬康恩生物医药科技有限公司13720134139 086-15871494362 13720134139 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
T&W GROUP021-61551611 13296011611 · [email protected]

Related reactions

2 records
New reaction record

Compound notes

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