Basic information
- CAS
54533-85-6- Standard SMILES
CCN(CC)Cc1nccn1-c1ccc([N+](=O)[O-])cc1C(=O)c1ccccc1Cl- InChIKey
WZGBZLHGOVJDET-UHFFFAOYSA-N- Molecular formula
- C21H21ClN4O3
- Average molar mass
- 412.9 g/mol
- Monoisotopic mass
- 412.1302182
Overview
Nizofenone is a member of benzophenones.
Names & identifiers
- Preferred name
- Nizofenone
- IUPAC
- (2-chlorophenyl)-[2-[2-(diethylaminomethyl)imidazol-1-yl]-5-nitrophenyl]methanone
- English name
- Nizofenone
- Molecular formula
- C21H21ClN4O3
- Molecular weight
- 412.87
Names & synonyms
Nizofenone54533-85-6NizofenonaNizofenonum7A2NOC3R88DTXSID401014745RefChem:166178DTXCID2028563N06BX101-(2-(2-chlorobenzoyl)-4-nitrophenyl)-2-(diethylaminomethyl)imidazole((1-(2-(2-chlorobenzoyl)-4-nitrophenyl)-1H-imidazol-2-yl)methyl)diethylamineNizofenone [INN]
Show more names
EkonNY-9179MidafenoneNizofenone fumarateNizofenone USP/EP/BP1-[2-(2-Chlorobenzoyl)-4-nitrophenyl]-2-(diethylaminomethyl)-1H-imidazole2'-Chloro-2-[2-[(diethylamino)methyl]-1H-imidazol-1-yl]-5-nitrobenzophenone(2-chlorophenyl)-[2-[2-(diethylaminomethyl)-1-imidazolyl]-5-nitrophenyl]methanone(2-Chlorophenyl)[2-[2-(diethylamino)methyl]-1H-imidazol-1-y1]-5-nitmphenyl]methanone
(2-Chlorophenyl)(2-(2-((diethylamino)methyl)-1H-imidazol-1-yl)-5-nitrophenyl)methanone(2-chlorophenyl)-[2-[2-(diethylaminomethyl)imidazol-1-yl]-5-nitrophenyl]methanoneNizofenone (INN)2'-Chloro-2-(2-((diethylamino)methyl)imidazol-1-yl)-5-nitrobenzophenoneNizofenonum [INN-Latin]Nizofenona [INN-Spanish](2-Chlorophenyl)(2-{2-[(diethylamino)methyl]-1H-imidazol-1-yl}-5-nitrophenyl)methanoneNSC315856
Properties
Computed structural properties
- XLogP
- 4.1
- Topological polar surface area
- 84 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 7
- Heavy atoms
- 29
- Formal charge
- 0
- Complexity
- 569
Physicochemical properties
- Melting point
- 75 · 75-76°
- Boiling point
- 609.7 · 609.7±65.0 °C(Predicted)
- Density
- 1.28 · 1.28±0.1 g/cm3(Predicted)
- storage temp.
- 2 · 2-8°C
- pka
- 8.75 · 8.75±0.25(Predicted)
- FDA UNII
- 7 A2NOC3R88 · 7A2NOC3R88
- ATC code
- 6 BX10 · N06BX10
Chemistry & industry
Pharmacology
ATC Code
N - Nervous system
QN - Nervous system
MeSH Pharmacological Classification
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
Applications
DescriptionNizofenzone fumarate is a potent antianoxic agent reported of benefit to geriatric and stroke patients. In animal models nizofenzone is reported to have protective effects against anoxia, global ischemia or other conditions resulting from cerebral infarction. It is also claimed to be a sedative and anticonvulsant.
UsesNizofenone has the effect of prolonging survival time in local and global cerebral ischemia models, global cerebral ischemia-reperfusion models, and hypoxia models, and has the effect of improving brain function and shrinking cerebral embolism lesions. It is used for brain disorders caused by ischemia in the acute phase of mild to moderate subarachnoid hemorrhage.
Upstream & downstream products
Upstream raw materials
Related reactions
0 records
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Compound notes
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