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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 4618794Generated: October 23, 2026

Sulfo-SMCC sodium

4-[(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-Cyclohexanecarboxylic acid 2,5-dioxo-3-sulfo-1-pyrrolidinyl ester sodium salt (1:1) · 4-(N-M · Slfo-SMCC · SULFO-SMCC · Sulfo-SMCC sodium · Cream Intermediate · SMCC, WATER-SOLUBLE · Sulfo-SMCC SodiuM Salt

https://huagongshe.com/en/chemical/4618794

Sulfo-SMCC sodium molecular structure

Identifiers & Physical Properties

CAS No.92921-24-9
Molecular formulaC16H17N2NaO9S
Average molar mass436.4 g/mol
Monoisotopic mass436.0552454 g/mol
SMILESO=C(ON1C(=O)CC(S(=O)(=O)[O-])C1=O)C1CCC(CN2C(=O)C=CC2=O)CC1.[Na+]
InChIKeyVUFNRPJNRFOTGK-UHFFFAOYSA-M
PubChem CID4618794
DTXSIDDTXSID80404961

Chemical & Physical Properties

Topological polar surface area167
Hydrogen bond donors0
Hydrogen bond acceptors9
Rotatable bonds6
Heavy atoms29
Formal charge0
Complexity853
Melting point>270°C (dec.)
Storage conditionsInert atmosphere,Store in freezer, under -20°C
SolubilityH2O: soluble2.5mg/mLSoluble in water (2.5 mg/ml) and dimethyl formamide.
Physical statepowder
Colorwhite to light brown
StabilityMoisture Sensitive
InChIInChI=1S/C16H18N2O9S.Na.H/c19-12-5-6-13(20)17(12)8-9-1-3-10(4-2-9)16(23)27-18-14(21)7-11(15(18)22)28(24,25)26/h5-6,9-11H,1-4,7-8H2,(H,24,25,26)
InChIKeyVUFNRPJNRFOTGK-UHFFFAOYSA-M
SMILESO(N1C(CC(S(O)(=O)=O)C1=O)=O)C(C1CCC(CN2C(C=CC2=O)=O)CC1)=O.[NaH]
FDA UNIIHH32D7TN36
UNSPSC Code41116133
NACRESNA.47
GHS pictogramGHS07
Signal wordWarning
GHS hazard statementsH315-H319-H335
GHS precautionary statementsP261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard symbolsXi
Risk statements (R)36/37/38-20/21-61
Safety statements (S)26-45-53
Water hazard class (WGK)3
Customs code29251900
Storage class11 - Combustible Solids

Safety & Regulations

Water hazard class (WGK)3
Customs code29251900
Risk statements (R)36/37/38-20/21-61
Signal wordWarning
GHS pictogramGHS07
Hazard symbolsXi
Safety statements (S)26-45-53
Storage class11 - Combustible Solids
GHS hazard statementsH315-H319-H335
GHS precautionary statementsP261-P280a-P304+P340-P305+P351+P338-P405-P501a

Applications & Uses

Description

Sulfo-SMCC is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively.

Uses

A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. Spacer Arm: 11.6 Angstroms

Uses

A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. Spacer Arm: 11.6 Angstroms