Basic information
- CAS
1228559-81-6- Standard SMILES
Cc1cccc(C)c1CNc1cc(C(=O)NCCOC(=O)CCCC(=O)O)cn2c(C)c(C)nc12- InChIKey
GPHPBXRKAJSSIC-UHFFFAOYSA-N- Molecular formula
- C26H32N4O5
- Average molar mass
- 480.6 g/mol
- Monoisotopic mass
- 480.23727013
Overview
Linaprazan glurate is a small molecule drug. The usage of the INN stem '-prazan' in the name indicates that Linaprazan glurate is a proton pump inhibitor, not dependent on acid activation. Linaprazan glurate is under investigation in clinical trial NCT07037875 (A Study Comparing the Effect and Safety of Linaprazan Glurate to Lansoprazole in Participants With Erosive Esophagitis (EE) Due to Gastroesophageal Reflux Disease (GERD)). Linaprazan glurate has a monoisotopic molecular weight of 480.24 Da.
Names & identifiers
- Preferred name
- Linaprazan Glurate
- IUPAC
- 5-[2-[[8-[(2,6-dimethylphenyl)methylamino]-2,3-dimethylimidazo[1,2-a]pyridine-6-carbonyl]amino]ethoxy]-5-oxopentanoic acid
- English name
- Pentanedioic acid, 1-[2-[[[8-[[(2,6-dimethylphenyl)methyl]amino]-2,3-dimethylimidazo[1,2-a]pyridin-6-yl]carbonyl]amino]ethyl] ester
- Molecular formula
- C26H32N4O5
- Molecular weight
- 480.56
Names & synonyms
Linaprazan glurate1228559-81-6Linaprazan glurate [INN]3VG4D399DT1-(2-(((8-(((2,6-Dimethylphenyl)methyl)amino)-2,3-dimethylimidazo(1,2-a)pyridin-6-yl)carbonyl)amino)ethyl) pentanedioatePentanedioic acid, 1-(2-(((8-(((2,6-dimethylphenyl)methyl)amino)-2,3-dimethylimidazo(1,2-a)pyridin-6-yl)carbonyl)amino)ethyl) ester1-[2-[[[8-[[(2,6-Dimethylphenyl)methyl]amino]-2,3-dimethylimidazo[1,2-a]pyridin-6-yl]carbonyl]amino]ethyl] pentanedioatePentanedioic acid, 1-[2-[[[8-[[(2,6-dimethylphenyl)methyl]amino]-2,3-dimethylimidazo[1,2-a]pyridin-6-yl]carbonyl]amino]ethyl] esterRefChem:153490UNII-3VG4D399DT5-(2-(8-((2,6-Dimethylbenzyl)amino)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamido)ethoxy)-5-oxopentanoic acid5-[2-[[8-[(2,6-dimethylphenyl)methylamino]-2,3-dimethylimidazo[1,2-a]pyridine-6-carbonyl]amino]ethoxy]-5-oxopentanoic acid
Show more names
fast onset,Linaprazan glurate,gastric acid,gastrointestinal inflammatory diseases,peptic ulcer diseases,Inhibitor,inhibit
Properties
Computed structural properties
- XLogP
- 3.7
- Topological polar surface area
- 122 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 7
- Rotatable bonds
- 12
- Heavy atoms
- 35
- Formal charge
- 0
- Complexity
- 725
Physicochemical properties
- Density
- 1.25 · 1.25±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · Store at -20°C
- pka
- 4.6 · 4.60±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- FDA UNII
- 3 VG4D399DT · 3VG4D399DT
Chemistry & industry
Applications
UsesLinaprazan glurate inhibits exogenously or endogenously stimulated gastric acid secretion. Linaprazan glurate exhibits several advantageous properties, such as fast onset, high in vivo potency and/or long duration of action. Linaprazan glurate is useful in the research of gastrointestinal inflammatory diseases and peptic ulcer diseases (extracted from patent WO2010063876A1)[1].
Suppliers15 total
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
上海凌飞医药科技有限公司13764318709 · [email protected]
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD+8613676922317 · [email protected]
HANGZHOU LEAP CHEM CO., LTD.+86-571-87711850 +86-15355479329 · [email protected]
滁州市科迈尔化工科技有限公司0550-5196001 15000891977 · [email protected]
药璞(上海)医药科技有限公司50929289 18616309303 · [email protected]
上海臻励生物科技有限公司021-16621358918; 18516310516;16621358918;13045646768 · [email protected]
ATK CHEMICAL COMPANY LIMITED+undefined-21-51877795 · [email protected]
深圳市创鑫生物科技有限公司13417589054 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
Related reactions
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Compound notes
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