Basic information
- CAS
64118-86-1- Standard SMILES
CC(C)(N1CC1C#N)N1CC1C(N)=O- InChIKey
RPZOFMHRRHHDPZ-UHFFFAOYSA-N- Molecular formula
- C9H14N4O
- Average molar mass
- 194.23 g/mol
- Monoisotopic mass
- 194.11676108
Overview
Azimexon is azimexon (2-cyanaziridinyl-2-carbamoyl-aziridinyl-1-propane) is a derivative of 2-cyanaziridine. Immunostimulant which shows therapeutic effects in tumor models and experimental infections in vitro, enhancing T lymphocyte transformation and phagocytosis. The mode of action of azimexon is unknown. It has been suggested that azimexon may alkylate DNA. In cancer patients it increases leukocytosis, blood active T rosettes, T4/T8 ratio, and is used as an adjuvant to chemotherapy in the treatment of melanoma and myeloma.
Names & identifiers
- Preferred name
- Azimexone
- IUPAC
- 1-[2-(2-cyanoaziridin-1-yl)propan-2-yl]aziridine-2-carboxamide
- English name
- azimexon
- Molecular formula
- C9H14N4O
- Molecular weight
- 194.23
Names & synonyms
Azimexon64118-86-1azimexoneAzimexonumBM-12531BM-12,5314NJ842U6BZ2-(2-Cyanaziridinyl-(1))-2-(2-carbamoylaziridinyl-(1))propaneBM12,531BM 12,5312-AZIRIDINECARBOXAMIDE, 1-(1-(2-CYANO-1-AZIRIDINYL)-1-METHYLETHYL)-2-Aziridinecarboxamide, 1-(1-(2-cyano-1-aziridinyl)-1-methylethyl)
Show more names
1-[1-(2-Cyano-1-aziridinyl)-1-methylethyl]-2-aziridinecarboxamide2-Aziridinecarboxamide, 1-[1-(2-cyano-1-aziridinyl)-1-methylethyl]-
2-Aziridinecarboxamide, 1-[1-(2-cyano-1-aziridinyl)-1-methylethyl]RefChem:116117BM12531BM 12.5312-Cyanaziridinyl-2-carbamoyl-aziridinyl-1-propane264-679-7Azimexon [INN]1-[2-(2-cyanoaziridin-1-yl)propan-2-yl]aziridine-2-carboxamide
Database identifiers
- CAS
64118-86-1- PubChem CID
- 47294
- DTXSID
DTXSID60867055- ChEMBL
CHEMBL149579- UNII
- 4NJ842U6BZ
Properties
Computed structural properties
- XLogP
- -0.6
- Topological polar surface area
- 72.9 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 3
- Heavy atoms
- 14
- Formal charge
- 0
- Complexity
- 329
Physicochemical properties
- Melting point
- 151 · 151-155 °C(Solv: acetone (67-64-1))
- Boiling point
- 403.4 · 403.4±45.0 °C(Predicted)
- Density
- 1.29 · 1.29±0.1 g/cm3(Predicted)
- pka
- 16.09 · 16.09±0.20(Predicted)
- FDA UNII
- 4 NJ842U6BZ · 4NJ842U6BZ
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Suppliers1 total
上海昕凯医药科技有限公司21-619849051-1 18521059765 · [email protected]
Related reactions
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Compound notes
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