Basic information
- CAS
64544-07-6- Standard SMILES
CON=C(C(=O)N[C@@H]1C(=O)N2C(C(=O)OC(C)OC(C)=O)=C(COC(N)=O)CS[C@H]12)c1ccco1- InChIKey
KEJCWVGMRLCZQQ-OBEQYXGQSA-N- Molecular formula
- C20H22N4O10S
- Average molar mass
- 510.5 g/mol
- Monoisotopic mass
- 510.10566408
Names & identifiers
- Preferred name
- 1-(Acetyloxy)ethyl (6R,7R)-3-[(carbamoyloxy)methyl]-7-[2-(furan-2-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
- IUPAC
- 1-acetyloxyethyl (6R,7R)-3-(carbamoyloxymethyl)-7-[[2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
- English name
- Cefuroxime 1-acetoxyethyl ester
- Molecular formula
- C20H22N4O10S
- Molecular weight
- 510.47
Names & synonyms
SCHEMBL379336AKOS0302425911-(Acetyloxy)ethyl (6R,7R)-3-[(carbamoyloxy)methyl]-7-[2-(furan-2-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylateCeftinCCI 15641KefuroxCEFUROXIM AXETILCefuroxime Axetil (350 mg)sn407XimosZinatcxm-ax
Show more names
Cefaks
Database identifiers
- CAS
64544-07-6- PubChem CID
- 47419
- DTXSID
DTXSID0022775
Properties
Computed structural properties
- XLogP
- 0.9
- Topological polar surface area
- 214 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 12
- Rotatable bonds
- 12
- Heavy atoms
- 35
- Formal charge
- 0
- Complexity
- 968
Physicochemical properties
- Melting point
- 175 · 175-180 °C
- Boiling point
- 250 °C · 250°C (rough estimate)
- Density
- 1.3927 · 1.3927 (rough estimate)
- refractive index
- 1.6 · 1.6000 (estimate)
- storage temp.
- -20 °C · -20°C
- solubility
- 1 mg/mL · DMSO: soluble1mg/mL
- form
- powder
- pka
- 8.31 · 8.31±0.60(Predicted)
- color
- white to off-white
- Major Application
- pharmaceutical
- InChIKey
- KEJCWVGMRLCZQQ-UXXYIVIXSA-N
- SMILES
- N12[C@@]([H])([C@H](NC(/C(/C3=CC=CO3)=N\OC)=O)C1=O)SCC(COC(N)=O)=C2C(OC(OC(C)=O)C)=O
- CAS DataBase Reference
- 64544 · 64544-07-6(CAS DataBase Reference)
- FDA UNII
- 49 QDT0J8Z · Z49QDT0J8Z
- UNSPSC Code
- 41116107 · 41116107
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 2
- hs_code
- 2941906000
- Toxicity
- LD50 oral in rabbit: 200mg/kg
- Signal word
- Danger
- Symbol(GHS)
- GHS08
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H317-H334
- Hazard Classifications
- Resp. Sens. 1Skin Sens. 1
- Precautionary statements
- P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P261-P285-P304+P341-P342+P311-P501
- Hazardous Substances Data
- 64544-07-6(Hazardous Substances Data)
Chemistry & industry
Applications
UsesIt is the 1-(acetyloxy) ethyl ester of Cefuroxime (C248060), an injectable second generation cephalosporin with an excellent antibacterial activity. This ester has a broader spectrum of activity than cephalexin (first-generation) and is widely used to treat respiratory tract infections. Antibacterial.
Usesantiviral (opthalmic)
UsesCefuroxime 1-acetoxyethyl ester is an injectable second generation cephalosporin with an excellent antibacterial activity. This ester has a broader spectrum of activity than cephalexin (first-generation) and is widely used to treat respiratory tract infections.
Upstream & downstream products
Upstream raw materials
Downstream products
Suppliers100 total
国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
济南百隆化学有限公司[email protected] · [email protected]
HubeiwidelychemicaltechnologyCo.,Ltd
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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