Indeloxazine Hydrochloride
Basic information
- CAS
65043-22-3- Standard SMILES
C1=Cc2cccc(OCC3CNCCO3)c2C1.Cl- InChIKey
KEBHLNDPKPIPLI-UHFFFAOYSA-N- Molecular formula
- C14H18ClNO2
- Average molar mass
- 267.75 g/mol
- Monoisotopic mass
- 267.1026065
Overview
See also: Indeloxazine (has active moiety).
Names & identifiers
- Preferred name
- Indeloxazine Hydrochloride
- IUPAC
- 2-(3H-inden-4-yloxymethyl)morpholine;hydrochloride
- English name
- Indeloxazine hydrochloride
- Molecular formula
- C14H18ClNO2
- Molecular weight
- 267.75
Names & synonyms
indeloxazine hydrochloride65043-22-3Indeloxazine HClYM-08054-1CI-87415QZ6NE84ERefChem:923383ElenIndeloxazine (hydrochloride)Indeloxazine Hydrochloride; Indeloxazine HCl2-((1H-Inden-7-yloxy)methyl)morpholine hydrochlorideCI 874
Show more names
NoinCI874lCI-874lYM 08054Indeloxadine hydrochloride
YM 08054-12-(3H-inden-4-yloxymethyl)morpholine;hydrochloride(+-)-2-((Inden-7-yloxy)methyl)morpholine hydrochloride65043-22-3 (HCl)Morpholine, 2-[(1H-inden-7-yloxy)methyl]-, hydrochloride2-[(1H-inden-7-yloxy)methyl]Morpholine hydrochlorideIndeloxazine hydrochloride [USAN:JAN]UNII-15QZ6NE84E
Database identifiers
- CAS
65043-22-3- PubChem CID
- 47517
- DTXSID
DTXSID60983582- ChEMBL
CHEMBL2448146- UNII
- 15QZ6NE84E
Properties
Computed structural properties
- Topological polar surface area
- 30.5 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 3
- Heavy atoms
- 18
- Formal charge
- 0
- Complexity
- 279
Physicochemical properties
- Melting point
- 169 · 169-170°; mp 155-156°
- storage temp.
- Sealed in dry,Room Temperature
- FDA UNII
- 15 QZ6NE84E · 15QZ6NE84E
- RIDADR
- 3249 · 3249
- HazardClass
- 6.1 · 6.1(b)
- PackingGroup
- III
- Toxicity
- 50 in · LD50 in mice (mg/kg): 47 i.v. (Tachikawa)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- ridadr
- 3249
- Toxicity
- LD50 in mice (mg/kg): 47 i.v. (Tachikawa)
- hazard_class
- 6.1(b)
- packing_group
- III
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Drugs used to prevent SEIZURES or reduce their severity.
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems.
Applications
DescriptionIndeloxazine hydrochloride is a nootropic indicated for the treatment of senile dementia. In animal models indeloxazine reportedly enhances brain energy metabolism and monoamine content; its claimed protective effect on ischemia-induced amnesia is supported by the prolonged step-through latency in passive avoidance tests.
UsesAntidepressant.
Upstream & downstream products
Upstream raw materials
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Related reactions
1 records
Compound notes
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