Basic information
- CAS
66309-69-1- Standard SMILES
CN(C)CCn1nnnc1SCC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)Cc3csc(N)n3)[C@H]2SC1.Cl.Cl- InChIKey
BWRRTAXZCKVRON-DGPOFWGLSA-N- Molecular formula
- C18H25Cl2N9O4S3
- Average molar mass
- 598.6 g/mol
- Monoisotopic mass
- 597.0568692
Overview
Cefotiam dihydrochloride is the dihydrochloride salt of cefotiam. It has a role as an antibacterial drug. It contains a cefotiam.
Names & identifiers
- Preferred name
- Cefotiam Hydrochloride
- IUPAC
- (6R,7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)acetyl]amino]-3-[[1-[2-(dimethylamino)ethyl]tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;dihydrochloride
- English name
- Cefotiam hydrochloride
- Molecular formula
- C18H23N9O4S3.HCl
- Molecular weight
- 562.08
Names & synonyms
Cefotiam dihydrochlorideCEFOTIAM HYDROCHLORIDE66309-69-1Cefotiam hclCeradonAbbott-48999SCE 963CGP-14221/EAbbott 48999SCE-963H7V12WDZ937(R)-(2-(2-Amino-4-thiazolyl)acetamido)-3-(((1-(2-(dimethylamino)ethyl)-1H-tetrazol-5-yl)thio)methyl)-3-cephem-4-carboxylic acid dihydrochloride
Show more names
CEFOTIAM 2HCLSpizefCeftiamHalosporSporidynPansporinCefapicolPansporineKemisporinSepidnarin
NSC-758164CHEBI:31374DTXSID1045538Hydrochloride, CefotiamAbbott48999RefChem:56910SCE963DTXCID401768952
Database identifiers
- CAS
66309-69-1- PubChem CID
- 47896
- DTXSID
DTXSID1045538- ChEMBL
CHEMBL4303232- ChEBI
CHEBI:31374- UNII
- H7V12WDZ93
- EC Number
- 266-312-6
Properties
Computed structural properties
- Topological polar surface area
- 251 Ų
- Hydrogen bond donors
- 5
- Hydrogen bond acceptors
- 13
- Rotatable bonds
- 10
- Heavy atoms
- 36
- Formal charge
- 0
- Complexity
- 847
Experimental & physicochemical properties
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Physicochemical properties
- Melting point
- 93 °C · >93°C (dec.)
- Boiling point
- 94 ℃ · 94℃
- RTECS
- 367000 · XI0367000
- Flash point
- 110 ° · >110°(230°F)
- storage temp.
- 2 · Inert atmosphere,2-8°C
- solubility
- 2 O: · H2O: ≥22M
- form
- powder
- color
- white to tan
- Water Solubility
- Soluble in water
- Stability
- Hygroscopic
- InChIKey
- BWRRTAXZCKVRON-DGPOFWGLSA-N
- CAS DataBase Reference
- 66309 · 66309-69-1(CAS DataBase Reference)
- FDA UNII
- 7 V12WDZ93 · H7V12WDZ93
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 319 · H319
- Precautionary statements
- 305 · P305+P351+P338
- Hazard Codes
- Xi
- Risk Statements
- 36 · 36
- Safety Statements
- 26 · 26
- WGK Germany
- 3 · 3
- HS Code
- 2941906000 · 2941906000
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Danger
H315 (50%): Causes skin irritation [Warning Skin corrosion/irritation]
P233, P260, P261, P264, P264+P265, P271, P272, P280, P284, P302+P352, P304+P340, P305+P351+P338, P321, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P403, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 6 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Hazard Classes and CategoriesSkin Irrit. 2 (50%)
Safety data
- wgk
- 3
- hs_code
- 2941906000
- risk_code
- 36
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xi
- safety_code
- 26
- Hazard statements
- H319
- Precautionary statements
- P305+P351+P338
Chemistry & industry
Pharmacology
MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.
Applications
DescriptionCefotiam was synthesized by Takeda Chemicals Industries in 1977 as the first cephem derivative to introduce the aminothiazol group in the 7 side chain and the alkylated tetrazole group at the 3 side chain . This drug shows greater antibacterial activity against gram-negative bacteria than the earlier cephalosporins, including Enterobacter, Citrobacter, and indole-positive Proteus, and it retains the same activity as they have against gram-positive organisms. Its excellent activity against Klebsiella and Escherichia coli is based on its ability to penetrate the cell. This is 3- to 70-fold greater than that of cephalothin or cefazolin.
UsesCefotiam hydrochloride (SCE-963 hydrochloride) is a parenteral cephalosporin antibiotic. Cefotiam has broad-spectrum activity against Gram-positive and Gram-negative bacteria.
Suppliers100 total
国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
济南百隆化学有限公司[email protected] · [email protected]
苏州朗恩生物科技有限公司13921996628 · [email protected]
Baoji Guokang Healthchem co.,ltd+8615604608665 15604608665 · [email protected]
Hebei Henghe Import and Export Trading Co. LTD+8618032935937 18032916000 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
江西瑞威尔生物科技有限公司400-880-2824 18107960669 · [email protected]
大连美仑生物技术有限公司0411-62910999 13889544652 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
武汉凯威斯科技有限公司86-027-67849912 · [email protected]
梯希爱（上海）化工贸易有限公司021-61109150 · [email protected]
上海泰坦科技股份有限公司4006009262 13023226327 · [email protected]
MedChemexpress LLC021-58955995 · [email protected]
孝感深远化工有限公司15527621225; 15527621225 · [email protected]
上海敬康生物医药科技有限公司021-34502253 13391330186 · [email protected]
湖南汇百侍生物科技有限公司0731-85526065 13308475853 · [email protected]
海南满方园医药有限公司0898-65315979 13307521111 · [email protected]
Wuhan NCE Biomedical Co.,Ltd.4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
广州爱纯医药科技有限公司020-39119399 18927568969 · [email protected]
南京生利德生物科技有限公司025-57798810 18652991625 · [email protected]
上海昶衍化工科技有限公司021-20242659 18930833303 · [email protected]
湖北威德利化学试剂有限公司186-02735115 18602735115 · [email protected]
北京环宇世纪化学科技有限公司hysj_bj.com
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
杭州杰恒化工有限公司0571-87396432 · [email protected]
上海永叶生物科技有限公司86-021-61559134 15921386130 · [email protected]
武汉励合化学新材料有限公司027-88395709
苏州麦凯尔生物医药科技有限公司15952441622 · [email protected]
陕西缔都医药化工有限公司029-81024372 17792795018 · [email protected]
凯试（上海）科技有限公司021-50135380 · [email protected]
池州凯隆进出口贸易有限公司[email protected]
江苏倍达医药科技有限公司0512-63009836 18994340901 · [email protected]
TargetMol中国（陶术生物）021-021-33632979 15002134094 · [email protected]
南京励合化学新材料有限公司025-87787262
Hebei Runbin Biotechnology Co. LTD13180553332 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
湖北威德利化学科技有限公司027-83989310 18627915365 · [email protected]
湖北威德利化学试剂有限公司18327179646 · [email protected]
武汉鑫儒化工有限公司15927387915 15337108568 · [email protected]
厦门志信化学有限公司+86-5922680277 +86-13806087780 · [email protected]
泰安嘉岳生物化工有限公司15318151873 · [email protected]
广东翁江化学试剂有限公司0751-2886766 13927870850 · [email protected]
湖北源梦生物科技有限公司027-68897569 18120462897 · [email protected]
武汉多普乐生物医药有限公司+86-02787215551 19945035818 · [email protected]
上海珞珐生化科技有限公司021-51111890 15317326293 · [email protected]
BOC Sciences16314854226 · [email protected]
陕西缔都医药化工有限公司+86-29-81139210 +86-17392587031 · [email protected]
南京艾比克斯生化科技有限公司025-87193546 18652950785 · [email protected]
上海思言生物科技有限公司021-50908862，442785678，326799392 18721037013 · [email protected]
Additional notes
DefinitionChEBI: Cefotiam dihydrochloride is the dihydrochloride salt of cefotiam. It has a role as an antibacterial drug. It contains a cefotiam.
Related reactions
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Compound notes
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