Basic information
- CAS
344458-19-1- Standard SMILES
CN(C)CC(=O)Nc1ccc2[nH]c(=O)c3ccccc3c2c1- InChIKey
UYJZZVDLGDDTCL-UHFFFAOYSA-N- Molecular formula
- C17H17N3O2
- Average molar mass
- 295.34 g/mol
- Monoisotopic mass
- 295.13207679
Overview
PJ34 is a member of the class of phenanthridines that is 5,6-dihydrophenanthridine substituted at positions 2 and 6 by (N,N-dimethylglycyl)amino and oxo groups, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 110 nM and 86 nM, respectively) and exhibits anti-cancer, cardioprotective and neuroprotective properties. It has a role as an antiatherosclerotic agent, an antineoplastic agent, an angiogenesis inhibitor, an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor, a neuroprotective agent, an anti-inflammatory agent, an apoptosis inducer and a cardioprotective agent. It is a secondary carboxamide, a tertiary amino compound and a member of phenanthridines. It is a conjugate base of a PJ34(1+).
Names & identifiers
- Preferred name
- PJ-34
- IUPAC
- 2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide
- English name
- PJ34
- Molecular formula
- C17H17N3O2
- Molecular weight
- 295.34
Names & synonyms
PJ34344458-19-1pj-342-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamideAcetamide, N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)-PJ 34NA92ZAR7N2CHEBI:167900RefChem:854982N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamideCHEMBL372303
Show more names
CS-856PJ34(free base)PJ34, 10 mM in DMSOPJ34 PJ-34 A3729 A-3729N,N-Dimethyl-2-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamideN-(6-OXO-5,6-DIHYDRO-PHENANTHRIDIN-2-YL)-N,N-DIMETHYLACETAMIDE HCL
P34N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)acetamide356042-41-6UYJZZVDLGDDTCL-UHFFFAOYSA-NPJ34 free basePJ34(free base)?1xk9SCHEMBL422317
Database identifiers
- CAS
344458-19-1
Properties
Computed structural properties
- XLogP
- 1.7
- Topological polar surface area
- 61.4 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 3
- Heavy atoms
- 22
- Formal charge
- 0
- Complexity
- 438
Experimental & physicochemical properties
DrugsPharmaceuticals -> Listed in ZINC15
Physicochemical properties
- storage temp.
- -20 °C · Sealed in dry,Store in freezer, under -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- color
- Light yellow to khaki
- FDA UNII
- 92 ZAR7N2 · NA92ZAR7N2
- UNSPSC Code
- 12352200 · 12352200
- NACRES
- 77 · NA.77
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 317 · H317-H319
- Precautionary statements
- 280 · P280-P305+P351+P338
- WGK Germany
- 2 · WGK 2
- Storage Class
- 12 · 12 - Non Combustible Liquids
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- WGK 2
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Storage Class
- 12 - Non Combustible Liquids
- Hazard statements
- H317-H319
- Precautionary statements
- P280-P305+P351+P338
Chemistry & industry
Applications
UsesPJ34 is a potent specific inhibitor of PARPl/2 with IC50 of 110 nM and 86 nM, respectively.
Suppliers55 total
陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
阿诺西（上海）生物技术有限公司400-1107768 15058188853 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
湖北科乐精细化工有限公司027-59101668 19945030958 · [email protected]
上海波以尔化工有限公司[email protected]
欧利希（湖北）医药科技有限公司17316404525 17316404525 · [email protected]
河南阿尔法化工有限公司0371-55013243 15324716602 · [email protected]
InvivoChem中国13549236410 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
Related reactions
2 records
Compound notes
Loading…