Linezolid N-oxide

HCID 486305

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Basic information

CAS: 189038-36-6
Standard SMILES: CC(=O)NC[C@H]1CN(c2ccc([N+]3([O-])CCOCC3)c(F)c2)C(=O)O1
InChIKey: CMFKNYFIQWSUNN-ZDUSSCGKSA-N
Molecular formula: C16H20FN3O5
Average molar mass: 353.35 g/mol
Monoisotopic mass: 353.13869891

Names & identifiers

Preferred name: Linezolid N-oxide
IUPAC: N-[[(5S)-3-[3-fluoro-4-(4-oxidomorpholin-4-ium-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
English name: Linezolid N-Oxide
Molecular formula: C16H20FN3O5
Molecular weight: 353.35

Names & synonyms

Linezolid N-Oxide189038-36-64JD2DSM8PQRefChem:1088482(S)-4-(4-(5-(Acetamidomethyl)-2-oxooxazolidin-3-yl)-2-fluorophenyl)morpholine 4-oxideLinezolid N-oxide [USP IMPURITY]UNII-4JD2DSM8PQN-[[(5S)-3-[3-fluoro-4-(4-oxidomorpholin-4-ium-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamideN-(((5S)-3-(3-Fluoro-4-(4-oxido-4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl)methyl)acetamideN-[[(5S)-3-[3-Fluoro-4-(4-oxido-4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamideAcetamide, N-(((5S)-3-(3-fluoro-4-(4-oxido-4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl)methyl)-Linezolid?N-Oxide

Show more names

Linezolid-1Linezolid-004-SLinezolid impurity CLinezolid Impurity219Linezolid Impurity1294Linezolid nitrogen oxideLinezolid Impurity A(USP)Linezolid Impurity N-OxideLinezolid N-Oxide Impurity

N-[[(5S)-3-[3-fluoro-4-(4-oxido-4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide; Acetamide, N-[[3-[3-fluoro-4-(4-oxido-4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-, (S)- (9CI); Linezolid N-OxideLinezolid N-Oxide, Linezolid ImpurityPNU-141535IL184105F578491A1-03014N-({(5S)-3-[3-Fluoro-4-(4-hydroxymorpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamideN-[[(5S)-3-[3-fluoro-4-(4-oxidomorpholin-4-ium-4-yl)phenyl]-2-oxo-oxazolidin-5-yl]methyl]acetamide

Database identifiers

CAS: 189038-36-6
PubChem CID: 486305
UNII: 4JD2DSM8PQ

Properties

Computed structural properties

XLogP: -0.1
Topological polar surface area: 85.9 Å²
Hydrogen bond donors: 1
Hydrogen bond acceptors: 6
Rotatable bonds: 4
Heavy atoms: 25
Formal charge: 0
Complexity: 514

Physicochemical properties

Melting point: 153 °C · >153°C (dec.)
storage temp.: -20 °C · Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 15.53 · 15.53±0.46(Predicted)
color: White to Off-White
Major Application: pharmaceutical small molecule
FDA UNII: 4 JD2DSM8PQ · 4JD2DSM8PQ

Chemistry & industry

Applications · 1 item

UsesLinezolid N-oxide is a derivative of Linezolid (L466500), an oxazolidinone antimicrobial that is used to treat infections against gram-positive bacteria, especially those that are drug-resistant (such as Vancomycin [HCl: V096500] resistant enterococci). Linezolid works by inhibiting bacterial protein synthesis.

Suppliers85 total

天津始加生物医药科技有限公司15022261580 · [email protected]

上海策嵘生物科技有限公司[email protected]

Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]

湖北威德利化学试剂有限公司186-02735115 18062128043 · [email protected]

济南百隆化学有限公司[email protected] · [email protected]

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