Basic information
- CAS
65240-86-0- Standard SMILES
O=C(NC1=CC(=O)c2ccccc2C1=O)c1ccccc1- InChIKey
BIVQBWSIGJFXLF-UHFFFAOYSA-N- Molecular formula
- C17H11NO3
- Average molar mass
- 277.27 g/mol
- Monoisotopic mass
- 277.07389321
Overview
PPM-18 is a naphthoquinone.
Names & identifiers
- Preferred name
- Ppm-18
- IUPAC
- N-(1,4-dioxonaphthalen-2-yl)benzamide
- English name
- 2-BENZOYLAMINO-1,4-NAPHTHOQUINONE
- Molecular formula
- C17H11NO3
- Molecular weight
- 277.27
Names & synonyms
ppm-18DTXSID80274449PPM 18RefChem:929916DTXCID5022592865240-86-0NQN-1n-(1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzamideN-(1,4-dioxonaphthalen-2-yl)benzamide2-Benzamido-1,4-naphthoquinoneMLS002693850SMR001559791
Show more names
NQN-1 (PPM-18)Benzamide, N-(1,4-dihydro-1,4-dioxo-2-naphthalenyl)-
2-Benzoylamino-1,4-naphthoquinoneNSC 732332-Benzamido- 1,4-naphthoquinoneN-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)benzamide; N-(1,4-Dioxo-1,4-dihydronaphthalen-2-yl)benzamide; NSC 73233; PPM 18NSC73233MFCD18427708cid_4882NCIOpen2_004005
Database identifiers
- CAS
65240-86-0- PubChem CID
- 4882
- DTXSID
DTXSID80274449- ChEMBL
CHEMBL1717890- ChEBI
CHEBI:185746- Nikkaji
- J738.755E
Properties
Computed structural properties
- XLogP
- 2.9
- Topological polar surface area
- 63.2 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 2
- Heavy atoms
- 21
- Formal charge
- 0
- Complexity
- 488
Physicochemical properties
- Melting point
- 134 · 134-136°C
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
- form
- Solid
- color
- Yellow to Orange
Chemistry & industry
Applications
Uses2-Benzamido-1,4-naphthoquinone belongs to a novel class of small molecule inhibitors of histone deacetylase (HDAC6), a family of enzymes that play significant role in numerous biological processes and diseases. 2-Benzamido-1,4-naphthoquinone was also shown to be an activation blocker of nuclear factor-kB (NF-kB).
Suppliers23 total
沈阳中申泽康生物医学技术研究有限公司024-88590548 18698872706 · [email protected]
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
Aladdin Scientific[email protected]
InvivoChem中国13549236410 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
BOC Sciences1-631-485-4226; 16314854226 · [email protected]
上海陶素生化科技有限公司021-33632979 · [email protected]
杭州六可生物科技有限公司+86-0571-86912261 +86-15658003402 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
Jurong Coupling Biotechnology Co., Ltd.13656108824 · [email protected]
艾吉析科技（上海）有限公司17717235263 17717235263 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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