Basic information
- CAS
179324-22-2- Standard SMILES
CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)B(O)O- InChIKey
MWKOOGAFELWOCD-FKBYEOEOSA-N- Molecular formula
- C25H42BN3O6
- Average molar mass
- 491.4 g/mol
- Monoisotopic mass
- 491.3166662
Overview
a proteasome inhibitor
Names & identifiers
- Preferred name
- MG-262
- IUPAC
- [(1R)-3-methyl-1-[[(2S)-4-methyl-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]pentanoyl]amino]butyl]boronic acid
- English name
- Z-Leu-Leu-Leu-B(OH)2 (MG262)
- Molecular formula
- C25H42BN3O6
- Molecular weight
- 491.43
Names & synonyms
MG-262boro-LLLMG262MG 262RefChem:925837179324-22-2PS-IIIZ-Leu-Leu-Leu-B(OH)2CHEMBL114388[(1R)-3-methyl-1-[[(2S)-4-methyl-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]pentanoyl]amino]butyl]boronic acid549V4DP94W[(1R)-1-[[(2S)-2-[[(2S)-2-(benzyloxycarbonylamino)-4-methyl-pentanoyl]amino]-4-methyl-pentanoyl]amino]-3-methyl-butyl]boronic acid
Show more names
Z-Leu-Leu-Leu-B(OH)2 (MG262)Proteasome Inhibitor III - CalbiochemL-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1R)-1-borono-3-methylbutyl]-
C25H42BN3O6UNII-549V4DP94WZ-LLL-boronatestarbld0016848orb1704910SCHEMBL12384366DTXSID80170795GLXC-04475
Database identifiers
- CAS
179324-22-2- PubChem CID
Properties
Computed structural properties
- Topological polar surface area
- 137 Ų
- Hydrogen bond donors
- 5
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 15
- Heavy atoms
- 35
- Formal charge
- 0
- Complexity
- 653
Physicochemical properties
- Density
- 1.101 · 1.101±0.06 g/cm3(Predicted)
- storage temp.
- -20 C · -20C
- solubility
- 24.57 mg/mL · ≥24.57 mg/mL in DMSO; insoluble in H2O; ≥96.4 mg/mL in EtOH
- form
- White solid
- pka
- 9.69 · 9.69±0.43(Predicted)
- color
- White to off-white
- InChIKey
- MWKOOGAFELWOCD-FKBYEOEOSA-N
- FDA UNII
- 549 V4DP94W · 549V4DP94W
- UNSPSC Code
- 12352200 · 12352200
- WGK Germany
- 1 · WGK 1
- Storage Class
- 11 · 11 - Combustible Solids
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- WGK 1
- Storage Class
- 11 - Combustible Solids
Chemistry & industry
Applications
UsesMG-262 (Z-Leu-Leu-LeuB(OH)2; ZL3B) is a reversible proteasome inhibitor. MG-262 down-regulates VEGF receptor Flt-1. MG-262 inhibits cell growth and induces apoptosis in malignant cells. MG-262 induces reactive oxygen species (ROS). MG-262 can be used for anti-cancer study[1][2][3][4][5].
General DescriptionA boronic acid-based, reversible proteasome inhibitor that is structurally similar to MG-132 (Cat. No. 474790) but displays much higher potency (Ki = 0.03 nM versus 4 nM for MG-132).
Suppliers11 total
United Life Science020-82099279 18988968278 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
杭州专肽生物技术有限公司17342063383 · [email protected]
青岛海智微元生物科技有限公司18317699790 18317699790 · [email protected]
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司021-61415566 800-8193336 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
郑州艾克姆化工有限公司13303867194 · [email protected]
TargetMol中国（陶术生物）
Related reactions
0 records
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Compound notes
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