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Basic information
- CAS
352513-83-8- Standard SMILES
CC(=NN=C(N)N)c1cc(NC(=O)CCCCCCCCC(=O)Nc2cc(C(C)=NN=C(N)N)cc(C(C)=NN=C(N)N)c2)cc(C(C)=NN=C(N)N)c1- InChIKey
PWDYHMBTPGXCSN-UHFFFAOYSA-N- Molecular formula
- C34H52N18O2
- Average molar mass
- 744.914 g/mol
- Monoisotopic mass
- 744.4520629
Names & identifiers
- Preferred name
- N~1~,N~10~-Bis(3,5-bis{1-[(diaminomethylidene)hydrazinylidene]ethyl}phenyl)decanediamide
- IUPAC
- N~1~,N~10~-Bis(3,5-bis{1-[(diaminomethylidene)hydrazinylidene]ethyl}phenyl)decanediamide
- English name
- Semapimod
- Molecular formula
- C34H52N18O2
- Molecular weight
- 744.9
Names & synonyms
AXD-455Cni-1493Cni 1493CPSI 2364semapimodN,N'-Bis[3,5-bis[1-[(aminoiminomethyl)hydrazono]ethyl]phenyl]decanediamideDecanediamide, N1,N10-bis[3,5-bis[1-[2-(aminoiminomethyl)hydrazinylidene]ethyl]phenyl]-N,N'-bis[3-[(E)-N-(diaminomethylideneamino)-C-methylcarbonimidoyl]-5-[(Z)-N-(diaminomethylideneamino)-C-methylcarbonimidoyl]phenyl]decanediamide
Database identifiers
- CAS
352513-83-8- PubChem CID
- 492132
- DTXSID
DTXSID70870333- ChEMBL
CHEMBL4555760
Properties
Physicochemical properties
- Density
- 1.39 · 1.39
- pka
- 14.28 · 14.28±0.70(Predicted)
- FDA UNII
- 9 SGW2H1K8P · 9SGW2H1K8P
Chemistry & industry
Applications
UsesSemapimod, an inhibitor of proinflammatory cytokine production, can inhibit TNF-α, IL-1β, and IL-6. Semapimod inhibits TLR4 signaling (IC50≈0.3 μM). Semapimod inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod has potential in a variety of inflammatory and autoimmune disorders[1][2][3].
Suppliers11 total
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
台州南峰药物研究所[email protected] 13127117265 · [email protected]
金瓯生物医药（南京）有限公司13000000000 · [email protected]
苏州美石生物科技有限公司1173954148q · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
深圳市创鑫生物科技有限公司13417589054 · [email protected]
深圳市创鑫生物科技有限公司13417589054 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
BOC Sciences+1-631-485-4226 · [email protected]
南京世洲生物科技有限公司025-85560043 15850508050 · [email protected]
泰兴市海川生物科技有限公司19353112242 · [email protected]
Related reactions
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Compound notes
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