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Basic information
- CAS
83654-05-1- Standard SMILES
O=C(NCCCCCCNC(=O)ON=C1CCCCC1)ON=C1CCCCC1- InChIKey
RXSVYGIGWRDVQC-UHFFFAOYSA-N- Molecular formula
- C20H34N4O4
- Average molar mass
- 394.516 g/mol
- Monoisotopic mass
- 394.25800557
Names & identifiers
- Preferred name
- (Hexane-1,6-diyldiimino)bis{[(cyclohexylideneamino)oxy]methanone}
- IUPAC
- [Hexane-1,6-diylbis(azanediyl)]bis{[(cyclohexylideneamino)oxy]methanone}
- English name
- 1,6-Bis(cyclohexyloximinocarbonylamino)hexane
- Molecular formula
- C20H34N4O4
- Molecular weight
- 394.52
Names & synonyms
U-57908Rg 80267RHC-80267RHC 80267, 10 mM in DMSORXSVYGIGWRDVQC-UHFFFAOYSA-NRHC-80267 - CAS 83654-05-1 - Calbiochem1,6-bis(cyclohexyloximinocarbonyl)hexaneRHC-80267, diacylglycerol lipase inhibitor1,6-Bis(cyclohexyloximinocarbonylamino)hexane1,6-Di(o-(carbamoyl)cyclohexanone oxime)hexane
Database identifiers
- CAS
83654-05-1- PubChem CID
- 5063
- DTXSID
DTXSID90232494- ChEMBL
CHEMBL158897- ChEBI
CHEBI:92984- UNII
- 9VB68H5WIT
- Nikkaji
- J37.285D
Properties
Physicochemical properties
- Melting point
- 118 · 118-121℃
- Density
- 1.21 · 1.21±0.1 g/cm3(Predicted)
- RTECS
- 1485000 · GW1485000
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- 9 mg/mL · DMSO: 9 mg/mL
- form
- solid
- pka
- 13.81 · 13.81±0.46(Predicted)
- color
- white
- Stability
- 2 years · Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
- InChI
- 1S/C20H34N4O4/c25-19(27-23-17-11-5-3-6-12-17)21-15-9-1-2-10-16-22-20(26)28-24-18-13-7-4-8-14-18/h1-16H2,(H,21,25)(H,22,26)
- InChIKey
- RXSVYGIGWRDVQC-UHFFFAOYSA-N
- SMILES
- O=C(NCCCCCCNC(=O)O\N=C1/CCCCC1)O\N=C2/CCCCC2
- EWG's Food Scores
- 1 · 1
- FDA UNII
- 9 VB68H5WIT · 9VB68H5WIT
- UNSPSC Code
- 51111800 · 51111800
- NACRES
- 77 · NA.77
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319-H335
- Precautionary statements
- 261 · P261-P305+P351+P338
- PPE
- 95 · Eyeshields, Gloves, type N95 (US)
- Safety Statements
- 22 · 22-24/25
- WGK Germany
- 3 · 3
Safety & regulation
Safety data
- PPE
- Eyeshields, Gloves, type N95 (US)
- wgk
- 3
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- safety_code
- 22-24/25
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P305+P351+P338
Chemistry & industry
Applications
DescriptionRHC-80267 (83654-05-1) inhibits DAG Lipase activity in a variety of cell types and tissues, including canine platelets, bovine adrenal chromaffin cells, human adrenal glomerulosa cells, rat thyroid lobes and pancreatic minilobules. IC50 in canine platelets is 4 μM.1
UsesRHC-80267 is a selective inhibitor of DAG lipase, which plays an important role in the production of arachidonic acid.
General DescriptionSelective inhibitor of DAG lipase activity in canine platelets (IC50 = 4 nM) and in a variety of mammalian cells. Also inhibits glucose- and carbachol-induced insulin release from intact islets. An inhibitor of Angiotensin II (Cat. No. 05-23-0101) and ATP-induced synthesis of 6-keto-prostaglandin F1α.
Suppliers39 total
陕西缔都新材料有限公司81124267 17392282731 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
上海微佳禾生物科技有限公司17502176150; 17502176150 · [email protected]
北京索莱宝科技有限公司010-50973130 17801761073 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
Related reactions
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Compound notes
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