Bis(dichlorophosphoryl)methane

HCID 5063078CAS 1499-29-2

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Basic information

Standard SMILES: O=P(Cl)(Cl)CP(=O)(Cl)Cl
InChIKey: VRXYCDTWIOCJBH-UHFFFAOYSA-N
Molecular formula: CH2Cl4O2P2
Average molar mass: 249.785 g/mol
Monoisotopic mass: 247.82841328

Names & identifiers

Preferred name: Bis(dichlorophosphoryl)methane
IUPAC: Methylenebis(phosphonic dichloride)
English name: METHYLENEBIS(PHOSPHONIC DICHLORIDE)
Molecular formula: CH2Cl4O2P2
Molecular weight: 249.78

Names & synonyms

bis(dichlorophosphoryl)methaneP,P'-methanediyl-bis-phosphonic acid tetrachlorideBIS(DICHLOROPHOSPHONYL)METHANEMETHYLENEDIPHOSPHONIC DICHLORIDEBis-(dichlorophosphinyl)-methaneMethylenedisphosphonic DichlorideMETHYLENEBIS(PHOSPHONIC DICHLORIDE)P,P′-Methylenebis[phosphonic dichloridePhosphonic dichloride, P,P'-methylenebis-

Database identifiers

CAS: 1499-29-2
PubChem CID: 5063078
DTXSID: DTXSID10407940
EC Number: 627-821-2
Nikkaji: J658.550G

Properties

Physicochemical properties

Melting point: 102 · 102-104 °C(lit.)
Boiling point: 329 · 329.0±25.0 °C(Predicted)
Density: 1.798 · 1.798±0.06 g/cm3(Predicted)
storage temp.: 2 · Storage temp. 2-8°C
solubility: Chloroform (Slightly), DMSO (Sparingly), Ethyl Acetate (Sparingly), Methanol (Slightly)
form: crystalline powder
color: Faint beige
Stability: Moisture Sensitive
InChI: InChI=1S/CH2Cl4O2P2/c2-8(3,6)1-9(4,5)7/h1H2
InChIKey: VRXYCDTWIOCJBH-UHFFFAOYSA-N
SMILES: P(Cl)(Cl)(=O)CP(Cl)(Cl)=O
UNSPSC Code: 12352100 · 12352100
NACRES: 22 · NA.22
Symbol(GHS): 5 · GHS05
Signal word: Danger
Hazard statements: 314 · H314
Precautionary statements: 260 · P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363
PPE: 3 · Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Hazard Codes: C
Risk Statements: 14 · 14-34
Safety Statements: 26 · 26-27-36/37/39-45
RIDADR: 3261 · UN 3261 8/PG 1
WGK Germany: 3 · 3
HS Code: 2931599090 · 2931599090
Storage Class: 8 A · 8A - Combustible corrosive hazardous materials
Hazard Classifications: 1 Skin · Eye Dam. 1Skin Corr. 1B

Safety & regulation

Safety data

PPE: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
wgk: 3
ridadr: UN 3261 8/PG 1
hs_code: 2931599090
risk_code: 14-34
Signal word: Danger
Symbol(GHS): GHS05
hazard_code: C
safety_code: 26-27-36/37/39-45
Storage Class: 8A - Combustible corrosive hazardous materials
Hazard statements: H314
Hazard Classifications: Eye Dam. 1Skin Corr. 1B
Precautionary statements: P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363

Chemistry & industry

Applications · 2 items

DescriptionMethylenebis (phosphonic dichloride) is an organophosphorus compound commonly used in phosphonation reactions. It is more reactive and faster than POCl. This is due to the fact that the phosphorus centre is more electrophilic due to the lack of electron feedback from the CH2 group.

UsesMethylenebis(phosphonic Dichloride) is used as a reagent in synthesis of several organic compounds including that of nucleoside 5'-methylenebis(phosphonate)s and bisphosphonated glycopeptide prodrugs for the treatment of osteomyelitis.

Upstream & downstream products

Upstream raw materials

Suppliers50 total

湖北万得化工有限公司15377098680 15377098680 · [email protected]

Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]

Hebei Zhuanglai Chemical Trading Co Ltd+86-16264648883 · [email protected]

河南多贝化工有限公司0370-6999054 17550096163 · [email protected]

杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]

Related reactions

1 records

New reaction record

HRID 337398As reactantuspto-grants-2014_11

Linked notes

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