Water → HCID 117698973, compound

HRID 337398

Reaction equation

HRID 337398 reaction equation
[CH2:1](P(Cl)(Cl)=O)[P:2]([Cl:5])([Cl:4])=[O:3].O[C:11]1[CH:24]=[CH:23][C:14]([C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:16])=[CH:13][CH:12]=1.N1C=CC=CC=1.O>C(Cl)Cl>[C:15]([C:17]1[CH:22]=[CH:21][C:20]([CH2:1][P:2]([Cl:5])([Cl:4])=[O:3])=[CH:19][CH:18]=1)(=[O:16])[C:14]1[CH:23]=[CH:24][CH:11]=[CH:12][CH:13]=1

Participants

6

Reactant 4

HCID 962WaterHCID 1049PyridineHCID 143474-HydroxybenzophenoneHCID 5063078Methylenebis(phosphonic dichloride)

Product 1

HCID 117698973HCID 117698973, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A degradable linking agent is formed by reacting methylenebis(phosphonic dichloride) (1 eq) with 4-hydroxybenzophenone (2 eq) in anhydrous DCM using pyridine (2.5 eq) as a base. The resulting product can be converted into its salt to increase water solubility.

Workup

  1. customis formed

Sources & evidence

ORD record
ord-c2e3305fb560461db910a7b100420e5b
Source dataset
uspto-grants-2014_11
Patent number
US08889760B2

Linked notes

Loading…