35-Azido-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontan-1-amine
Azido-PEG11-NH2 · N3-PEG11-NH2 · Amino-PEG12-azide · Azido-PEG11-amine · 1-azido-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontan-5-amine · 35-Azido-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontan-1-amine · 35-Amino-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontanyl Azide · 1-Amino-35-azido-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontane
Identifiers & Physical Properties
| CAS No. | 1800414-71-4 |
|---|---|
| Molecular formula | C24H50N4O11 |
| Average molar mass | 570.7 g/mol |
| Monoisotopic mass | 570.34760842 g/mol |
| SMILES | [N-]=[N+]=NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN |
| InChIKey | SEFFQZUNGHPPPA-UHFFFAOYSA-N |
| PubChem CID | 51340887 |
| EC No. | 833-543-4 |
| DTXSID | DTXSID801150981 |
Chemical & Physical Properties
| XLogP | -1.4 |
|---|---|
| Topological polar surface area | 142 |
| Hydrogen bond donors | 1 |
| Hydrogen bond acceptors | 14 |
| Rotatable bonds | 35 |
| Heavy atoms | 39 |
| Formal charge | 0 |
| Complexity | 507 |
| Storage conditions | Storage temp. -20°C |
| Physical state | clear liquid |
| Color | Colorless to Almost colorless |
| GHS pictogram | GHS07 |
| Signal word | Warning |
| GHS hazard statements | H315-H319 |
| GHS precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| Customs code | 2942000090 |
Safety & Regulations
| GHS classification | WarningH315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement)Aggregated GHS information provided per 2 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| Hazard Classes and Categories | Skin Irrit. 2 (100%) |
| Customs code | 2942000090 |
| Signal word | Warning |
| GHS pictogram | GHS07 |
| GHS hazard statements | H315-H319 |
| GHS precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
Applications & Uses
Description
Azido-PEG11-amine is a water soluble PEG compound. The azide group enables Click Chemistry. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG arm increases solubility in aqueous media.
Uses
Azido-PEG11-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG11-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.