1-Maleinimido-3-oxo-7,10,13,16-tetraoxa-4-azanonadecan-19-oic acid succinimidyl ester

DescriptionMal-amido-PEG4-NHS is a PEG linker containing a maleimide group and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

UsesMaleimide-PEG4-NHS (CAS# 756525-99-2) is a cross-linking compound used in the lysosomal acid-triggered release of anticancer drugs.

General DescriptionMaleimide-PEG4-NHS Ester (CAS 756525-99-2) is a high-purity, monodisperse polyethylene glycol (PEG) derivative. Its synonyms include Mal-amido-PEG4-NHS, Mal-amido-PEG4-NHS ester, Mal-NH-PEG4-NHS, MAL-NH-PEG4-NHS ESTER and Mal-NH-PEG4-CH₂CH₂COONHS, amongst others. This compound possesses three key functional groups: the Mal group, the PEG4 chain and the NHS ester. The Mal group is capable of forming covalent bonds with thiol groups without affecting the overall structure of the protein; the NHS ester enhances reactivity with primary amine groups, facilitating the formation of stable amide bonds; whilst PEG4 improves the hydrophilicity and biocompatibility of the conjugate, whilst also reducing aggregation and immunogenicity. Consequently, this substance is primarily used in the synthesis of protein conjugates, drug delivery research, diagnostic testing and materials science.